Pathogenic mutations were identified in 243 of 2398 patients, including 168 homozygous mutations and 75 compound heterozygous mutations. Three variants (c.225G>T, c.521G>A, and c.557C>T) are novel mutations.
Computing with words is a methodology in which concepts, linguistic values or words, instead of numbers for computing and reasoning. Cloud model is a novel cognitive model for uncertain transformation between linguistic concepts and quantitative values. It should go without saying that computing with words based on cloud model is an important research study direction. After the algebra operations rule of cloud model is introduced, this paper presents a simple statistical algorithm to solve the computational problem of algebra operations for cloud model. Then, it proves that the statistical algorithm could reach any given precision level as long as cloud drops increase. Finally, we analyze the character of the statistical algorithm and the relationship with the operations rule for cloud model.
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