Based on the New Diagnosis and Treatment Scheme for Novel Coronavirus Infected Pneumonia (Trial Edition 5), combined with our current clinical treatment experience, we recently proposed a revision of the first edition of "Guidance for maternal and fetal management during pneumonia epidemics of novel coronavirus infection in the Wuhan Tongji Hospital". This article focused on the issues of greatest concern of pregnant women including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnostic criteria, inspection precautions, drug treatment options, indications and methods of termination of pregnancy, postpartum fever, breastfeeding considerations, mode of mother-to-child transmission, neonatal isolation and advice on neonatal nursing, to provide valuable experience for better management of SARS-CoV-2 infection in pregnant women and newborns.

Many countries adopted lockdown measures to curb the spread of the outbreak in 2020, while information about COVID-19 has dominated various media outlets, which has led to information overload for people. However, previous research has mainly focused on cancer information overload and the corresponding consequence, and failed to examine its adverse effects in the context of major public health events. Based on the Frustrate Aggression Theory and the Scapegoat Theory, the present study established a moderated mediation model to investigate the emotional and behavioral outcomes of COVID-19 information overload. The mediating role of depression/anxiety in the association between COVID-19 information overload and cyber aggression, as well as the moderating role of Confucian responsibility thinking, were tested. This model was examined with 1005 Chinese people (mean age = 26.91 years, SD = 9.94) during the COVID-19 outbreak. Mediation analyses revealed that COVID-19 information overload was positively related to cyber aggression, depression, and anxiety, parallelly and partially mediated this relationship. Moderated mediation analyses further indicated that Confucian responsibility thinking not only moderated the direct link between COVID-19 information overload and cyber aggression, with the effect being significant only for people with a low level of Confucian responsibility thinking, but also moderated the relationship between COVID-19 information overload and depression/anxiety respectively, with the associations being much more potent for individuals with low levels of Confucian responsibility thinking. These findings have the potential to inform the development of prevention and intervention programs designed to reduce the negative emotions and cyber aggression associated with information overload in public health events.

OBJECTIVES: Adherence to a healthy diet has been associated with a reduced risk of type 2 diabetes (T2D). Hepatocellular carcinoma (HCC) may have overlapping mechanisms with T2D, such as inflammation and insulin resistance. Thus, we examined the association between a previously developed T2D prevention dietary pattern and HCC risk. METHODS: We followed 87,943 women in the Nurses' Health Study and 49,665 men in the Health Professionals Follow-up Study for up to 32 years. The dietary diabetes risk reduction score, which includes dietary glycemic index, cereal fiber, ratio of polyunsaturated to saturated fats, trans fat, sugar-sweetened beverages, nuts, coffee, and red and processed meats, was obtained using validated food frequency questionnaires and updated every 4 years. The Cox proportional hazards regression model was used to calculate multivariable hazard ratios and confidence intervals (95% CIs). RESULTS: During over 1.9 million person-years, a total of 160 incident HCC cases were identified. The dietary diabetes risk reduction score was associated with a lower risk of HCC (top vs bottom quartile; hazard ratio: 0.57, 95% CI: 0.34–0.95; P trend = 0.03). All the individual food and beverage items were associated with the risk of HCC in the expected direction, although the association was weaker than the overall dietary pattern. DISCUSSION: Greater adherence to the T2D prevention diet was associated with a lower risk of developing HCC among US men and women. Further studies are needed to confirm and extend our findings.

Highlights Low physical activity and obesity predicted an excess risk of liver-related death. The excess risk conferred by obesity was markedly attenuated by physical activity. Overall, walking for >3 hours/week could have prevented 25% of liver-related deaths.

The COVID-19 epidemic will persist for the foreseeable future. Given the significant toll the outbreak has taken on the healthcare system, identifying those patients with a greater need for medical attention is necessary. Recent studies suggest that obesity is associated with worse severity of COVID-19 pneumonia, increasing the need for hospitalization, critical care and mechanical ventilation. 1-6 T A B L E 1 Demographics, medical history, laboratory and pneumonia involvement (mm 3) for the four BMI groups Variables Normal weight Overweight Obese Underweight F/χ 2 value P (n = 84, 36.4%) (n = 105, 45.4%) (n = 33, 14.3%) (n = 9, <0.1%) Age, years

The SARS-CoV-2 infection status of hospitalized children was surveyed in the department of pediatric hematology and oncology in three different hospitals of epidemic areas in Hubei, China. A cross-sectional study was performed to investigate the clinical characteristics, lung CT scan, SARS-CoV-2 nucleic acid test and serum antibodies of hospitalized children with hemato-oncological diseases from January 23 to April 24, 2020. 299 children were enrolled in this study, including 176 males (58.9%) and 123 females (41.1%), aged from 2 months to 16 years. 255 cases (85.3%) received chemotherapy or other immunosuppressive therapies, and there were 44 cases (14.7%) of other benign diseases. Nucleic acid test was performed on 258 children (86.3%) and one case was positive. 163 cases (54.5%) were tested for serum antibodies, and all of them were negative. Lung CT scan was performed on 247 children (82.6%), and 107 of them showed infectious changes. Only one case (0.33%) of COVID-19 was diagnosed in the group. The prevalence rate of COVID-19 in enrolled children with hemato-oncological diseases in Hubei was 0.33%. Immunosuppressed patients are not prone to produce related antibodies. Comprehensive protective measures and ward management can reduce the risk of SARS-CoV-2 infection in the group patients.

No abstract

Summary In the period of regular epidemic prevention and control of Coronavirus disease 2019 (COVID-19) in our country, work resumption has been fully advanced. But there are still new sporadic local cases and imported cases across the country. In this situation, whether kindergartens reopening will increase the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread still remains uncertain. We reviewed two pediatric patients with moderate COVID-19, collected the epidemiologic information and monitored the cycle threshold value of rectal specimen and the viral loads, and discussed the transmission of SARS-CoV-2 in pediatric patients and the virulence of feces in children with moderate COVID-19, in order to analyze the risk of kindergartens reopening.