Background: Pkd2L1 is a calcium-and acid-activated channel likely involved in acid sensing, but how it is regulated remains unclear. Results: Receptor for activated C kinase 1 (RACK1), known to regulate various receptors/channels, interacts with and inhibits the function of Pkd2L1. Conclusion: Pkd2L1 is a novel target channel of RACK1. Significance: Pkd2L1-RACK1 interaction may play important physiological roles through regulating channel activation by calcium or acid.
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