Identification of Homer1 as a Potential Prognostic Marker for Intrahepatic Cholangiocarcinoma

Wu, Shuping; Mu, Yu; Li, Xiao-Gai; Xu, Shufang; Ji, Shen; Sun, Zhen; Zhou, Xin; Chen, Xing-Zhen; Tu, Jiancheng

doi:10.7314/apjcp.2014.15.7.3299

Cited by 6 publications

(7 citation statements)

References 28 publications

(22 reference statements)

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“…In our study, we found a possible tumor suppressive role of Homer1 in HCC. In contrast to our study, Wu et al 21 demonstrated that the expression of Homer1 in intrahepatic cholangiocarcinoma was higher than that in the adjacent tissues, suggesting an oncogenic role of Homer1. Interestingly, mRNA annexin A4 has been found to be decreased in prostate cancer 30 but increased in HCC 31 which revealed that there are genes act as oncogene or tumor suppressor in different cancers, we therefore deemed that Homer1 may play a diverse role in different tumors.…”

Section: Discussioncontrasting

confidence: 99%

“…Considering its vital role in keeping the homestasis of calcium in intracellular, we believe that Homer1 is involved in tumorigenesis. Furthermore, Wu et al 21 demonstrated that the expression of Homer1 in intrahepatic cholangiocarcinoma was higher than that in the adjacent tissues. Thus, it is particularly prospective to explore whether Homer1 can be a new biomarker for HCC.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, we assumed that there was a correlation between Homer1 and tumors. Wu et al 21 found that the expression of Homer1 in intrahepatic cholangiocarcinoma was higher than that in the adjacent tissues and its expression was negatively correlated with the 5 year survival rate of the patients. Meanwhile, Shin et al 22 revealed that various tumor cells (HeLa, HCT116, HEK 293, DU145, and A549) originated from tissues of cervix, colon, kidney, and lung express the significant amounts of Homer1 protein, indicating that Homer1 may play some roles in tumorigenesis.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and Diagnostic Significance of Homer1 in hepatitis B virus-induced Hepatocellular Carcinoma

Luo¹,

Feng²,

Wei³

et al. 2018

J. Cancer

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Background: Hepatocellular carcinoma (HCC) is a malignant tumor worldwide. Attributed to the lack of early diagnosis index, most patients are diagnosed in their late stage. Homer1, as a member of scaffold protein family, is made up of two different isoforms: Homer1a and Homer1b/c. More and more evidences show that Homer1 is dysregulated in cancers. Here, in this study, we investigated the expression profile, clinical, diagnostic and prognostic significance of Homer1 in hepatitis B virus-induced HCC (HBV-HCC).Methods: We first tested the expression of Homer1 in HCC cell lines by quantitative real-time PCR (qRT-PCR), western blot. Then, 86 pairs of tumorous and adjacent normal tissues from HCC together with a total number of 245 peripheral blood samples were enrolled to check the expression levels of Homer1 by quantitative real-time PCR (qRT-PCR).Results: The results revealed that the levels of Homer1 were both downregulated in HCC cell line and tissue and were associated with tumor size, but were not related to the prognosis of HBV-HCC. Receiver-operating characteristic curve analyses indicated that the sensitivity of Homer1 to differentiate HCC patients from the controls was high to 100.0% and the combination of Homer1 and AFP got a higher prediction value of HCC (AUC=0.890).Conclusion: Our data highlighted that Homer1 played a critical role in HCC tumorigenesis and might be a potential diagnostic marker for HCC.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical and Diagnostic Significance of Homer1 in hepatitis B virus-induced Hepatocellular Carcinoma

Luo¹,

Feng²,

Wei³

et al. 2018

J. Cancer

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“…These factors include staging [ 10 ], para-aortic lymph node status [ 11 ], positive node to the total node ratio [ 12 ], tumor size, and the presence of multiple tumors [ 13 ]. Other novel molecular biomarkers, such as hepatoma-derived growth factor [ 14 ], SOX4 [ 15 ], loss of FBXW7 expression [ 16 ], Homer1 [ 17 ], and inactivation of Smad4 [ 18 ], seem to be associated with poor IHCC patient prognosis. Despite these critical association findings, the majority of these histological predictors only apply to assessments conducted after surgical intervention.…”

Section: Introductionmentioning

confidence: 99%

Intrahepatic cholangiocarcinoma prognostic determination using pre-operative serum C-reactive protein levels

et al. 2016

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BackgroundSerum C-reactive protein (CRP), an acute inflammatory response biomarker, has been recognized as an indicator of malignant disease progression. However, the prognostic significance of CRP levels collected before tumor removal in intrahepatic cholangiocarcinoma requires further investigation.MethodsWe sampled the CRP levels in 140 patients with intrahepatic cholangiocarcinoma who underwent hepatectomies with regional lymphadenectomies between 2006 and 2013. A retrospective analysis of the clinicopathological data was performed. We focused on the impact of serum CRP on the patients’ cancer-specific survival and recurrence-free survival rates.ResultsHigh levels of preoperative serum CRP were significantly associated with well-established clinicopathologic features, including gender, advanced tumor stage, and elevated carcinoembryonic antigen and carbohydrate antigen 19-9 levels (P < 0.05). Univariate analysis demonstrated a significant association between high levels of serum CRP and adverse cancer-specific survival (P = 0.001) and recurrence-free survival (P < 0.001). In patients with stage I/II intrahepatic cholangiocarcinoma, the serum CRP level was a prognostic indicator for cancer-specific survival. In patients with stage I/II or stage III/IV, the serum CRP level was a prognostic indicator for recurrence-free survival (P < 0.05). Additionally, multivariate analysis identified serum CRP level in intrahepatic cholangiocarcinoma as an independent prognostic factor (P < 0.05).ConclusionsWe confirmed a significant association of elevated pre-operative CRP levels with poor clinical outcomes for the tested patients with intrahepatic cholangiocarcinoma. Our results indicate that the serum CRP level may represent a useful factor for patient stratification in intrahepatic cholangiocarcinoma management.

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“…4 Previous studies have reported that a significant amount of Homer1 protein expressed is observed in various tumor cells (such as HCT116, HeLa, HEK 293, A549, and DU145) originated from tissues of colon, cervix, lung and kidney, suggesting that Homer1 may play some roles in these tumor cells. [5][6][7][8][9] However, the precise role of Homer1 in colorectal cancer and the molecular mechanisms underlying its effects have not been elucidated.…”

Section: Introductionmentioning

confidence: 99%

<p>Homer1 is a Potential Biomarker for Prognosis in Human Colorectal Carcinoma, Possibly in Association with G3BP1 Signaling</p>

Cui¹,

Liang²,

Hao³

et al. 2020

CMAR

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Background: Homer scaffolding protein 1 (Homer1) is a postsynaptic scaffold protein that regulates the structure and function of excitatory synaptic as well as its intracellular signal transduction. However, the role of Homer1 in colorectal cancer as well as the underlying molecular mechanisms has not been elucidated. Materials and Methods: To evaluate the alternations of gene expression during colorectal cancer, Homer1 expression was analyzed using the gene expression profiling interactive analysis and Oncomine analyses. The prognostic value of Homer1 expression was validated by our own colorectal cancer specimens using RT-PCR. Then, the cell viability, migration and invasion of colorectal cancer cell lines were detected by CCK-8 and transwell assay. Results: We obtained the following important results. (1) Homer1 expression was significantly higher in colorectal cancer than normal samples. (2) Among patients with colorectal cancer, those with higher Homer1 expression had a lower survival rate. (3) The major mutation type of Homer1 in colorectal cancer samples was missense mutation. (4) Homer1 was able to promote colorectal cancer cell proliferation, migration, and invasion through upregulating G3BP1 in vitro. Conclusion:Our findings suggest that Homer1 may play a role in malignancy of colorectal cancer mainly through the G3BP1 signaling pathway, which might be a potential indicator of poor prognosis.

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Identification of Homer1 as a Potential Prognostic Marker for Intrahepatic Cholangiocarcinoma

Cited by 6 publications

References 28 publications

Clinical and Diagnostic Significance of Homer1 in hepatitis B virus-induced Hepatocellular Carcinoma

Clinical and Diagnostic Significance of Homer1 in hepatitis B virus-induced Hepatocellular Carcinoma

Intrahepatic cholangiocarcinoma prognostic determination using pre-operative serum C-reactive protein levels

<p>Homer1 is a Potential Biomarker for Prognosis in Human Colorectal Carcinoma, Possibly in Association with G3BP1 Signaling</p>

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