Utilizing microwave continuous-wave Doppler radars to wirelessly detect mechanical vibrations have been attracting more and more interests in recent years. In this paper, aiming to solve the null point and nonlinear issues in small-angle approximation-based Doppler radar sensors and eliminate the codomain restriction in the arctangent demodulation approach, we propose and investigate an extended differentiate and crossmultiply (DACM) algorithm. With an additional accumulator, the noise performance of the original DACM algorithm is improved.
Moreover, the amplitude information of the vibration can be directly retrieved from accumulation without involving any distance-dependent issue. Experimental validations show that the proposed algorithm can fully recover the vibration patterns with the measured noncalibrated amplitude agreeing well with the known precalibrated data. Application examples of mechanical fault detection and human vital sign detection are demonstrated, showing a wide range of potential applications of this algorithm.Index Terms-Arctangent demodulation, differentiate and cross multiply (DACM), noncontact vibration measurement, nonlinear phase modulation, radar sensor.
Cisplatin-based combination chemotherapy significantly improves the survival outcomes in non–small cell lung carcinomas (NSCLCs), but drug resistance commonly contributes to disease progression and relapse. Recently, accumulating evidence has indicated that deubiquitinases (DUBs) are involved in regulating tumor cell proliferation, apoptosis, and chemoresistance. We designed this study to investigate the role of WP1130, a DUB inhibitor, in regulating cisplatin cytotoxicity in NSCLCs. After being combined with WP1130, cisplatin sensitivity was significantly increased in A549 and HCC827 cells with decreased p53 expression, inhibiting their proliferation, but not in p53-deficient NCI-H1299 cells. The synergistic cytotoxicity of the cisplatin and WP1130 co-treatment was abolished in p53-knockdown cells. Western blotting verified the decreased p53 expression in A549 and HCC827 cells treated with cisplatin and WP1130. The administration of MG132, a proteasome inhibitor, or knockdown of ubiquitin-specific peptidase 9, X-linked (USP9X) both eliminated the effect of WP1130 in decreasing p53 expression. Taken together, our findings confirm that the inclusion of WP1130 is potentially contributes to better therapeutic effects of cisplatin-based chemotherapy of NSCLCs in a manner dependent on the USP9X–p53 ubiquitination–mediated degradation pathway.
A kind of Mach-Zehnder optical switch with a dual-bus coupled ring resonator as a two-beam interferometer is proposed and investigated. The analysis based on the transfer matrix method shows that a sharp asymmetric Fano line shape can be generated in the transmission spectra of such a configuration, which can be used to significantly reduce the phase change required for switching. Meanwhile, it can also be found that complete extinctions can be achieved in both switching states if the structural parameters are carefully chosen and the phase bias is properly set. Through tuning the phase difference between the arms of the Mach-Zehnder interferometer, complete extinction can be easily kept within a large range of the ring-bus coupling ratios in the OFF state. By properly modulating the phase change in the ring waveguide, the shift of the resonant frequency and the asymmetry of the transmission spectra can be controlled to finally enable optical switching with a high extinction ratio, even complete extinction, in the ON state. The switching functionality is verified by the finite-difference time-domain simulation.
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