Allenes are the simplest class of cumulenes, possessing unique physical and chemical properties. These structural units are widely used as valuable synthetic intermediates in organic synthesis, as well as the...

Heterocyclic compounds are important organic compounds and have emerged as key scaffolds in numerous drugs, natural products, vitamins, biologically and pharmaceutically active compounds. Over the past few decades, the development of versatile methodologies employing propargylic alcohols as synthons for the construction of heterocyclic skeletons has attracted great attention from synthetic chemists. In this review, recent developments in the cascade cyclization of propargylic alcohols with diverse nucleophiles to construct heterocyclic compounds are summarized. According to the types of nucleophiles, these reactions can be divided into four categories: 1) Reactions involving C‐nucleophiles to capture allenyl carbocation; 2) Reactions involving O, S‐nucleophiles to capture allenyl carbocation; 3) Reactions involving N, P‐nucleophiles to capture allenyl carbocation; 4) Reactions involving halo‐nucleophiles to capture allenyl carbocation.

Herein, a highly regioselective alkylation of propargylic carbonates for trisubstituted allenes with alkyl 1,4-dihydropyridines derivatives is developed via photoredox/ nickel dual-catalyzed process, which represents the first direct approach to access...

A novel, efficient and metal-free cascade sulfonylation/cyclization of 2-propynolphenols with commercially available sodium sulfinates was developed for the synthesis of 4-sulfonyl 2H-chromenes under mild conditions.

Here, we report a visible-light enabled platform for the photochemical reduction of 1,2-dicarbonyl compounds to α-hydroxy carbonyl derivatives which utilizes diisopropylethylamine (Hünig’s base) as a reductant. This reaction tolerates a...