Phytochemical investigation on the stem bark and wood of Trigonostemon chinensis led to the isolation of four new dinorditerpenoids, trigonostemons A-D (1, 3, 5, 6), a new phenanthrenone, trigonostemon E (7), and a new bisindole alkaloid, trigonostemon F (8). The structures were established by extensive spectroscopic methods. The absolute configurations of 1-6 were determined by X-ray crystallography, circular dichroism, quantum chemical TDDFT calculations, and chemical transformations. The relative configuration of 8 was confirmed by X-ray diffraction analysis.
Six new compounds, phochinenins A -F (1 -6), dimerized from 9,10-dihydrophenanthrene and dihydrostilbene through direct coupling or an oxygen bridge, along with eight known compounds, were isolated from the whole plants of Pholidota chinensis. Their structures were elucidated on the basis of extensive spectroscopic investigations (1D-, 2D-NMR, and HR-EI-MS).
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