Limonoids from the fruits of Melia toosendan

Zhang, Yi; Tang, Chunping; Ke, Chang‐Qiang; Li, Xi-Qiang; Xie, Hua; Yang, Yong

doi:10.1016/j.phytochem.2011.10.001

Cited by 38 publications

(34 citation statements)

References 27 publications

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“…It has been reported that two limonoids, isotoosendanin and 1-O-tigloyl-1-O-debenzoylohchinal, which were extracted from Melia toosendan, inhibited acetic acid-induced vascular permeability and l-carrageenan-induced paw edema in ICR mice and displayed significant antiinflammatory effect without causing acute toxicity in vivo (15). It has been recently reported that several novel limonoids had inhibitory effects against lipopolysaccharide (LPS)-induced NO production in RAW264.7 mouse macrophage cells (16,17). However, the antiinflammatory effect of nimbolinins in brain microglia has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

1-O-Tigloyl-1-O-deacetyl-nimbolinin B Inhibits LPS-Stimulated Inflammatory Responses by Suppressing NF-κB and JNK Activation in Microglia Cells

et al. 2014

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Abstract. Overactivation of microglia may contribute to the pathogenesis of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and HIV dementia. Thus, regulating microglial activation has been an important therapeutic strategy for treating neurodegenerative diseases. In this research, we compared three limonoids compounds extracted from Melia toosendan by a cell-based assay to investigate their anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated microglia cells. Our study indicated that 1-O-tigloyl-1-O-deacetyl-nimbolinin B (TNB) markedly suppressed the production of nitric oxide (NO) and tumor necrosis factor (TNF)-a in LPS-stimulated microglia cells. TNB also inhibited the gene expression of inducible nitric oxide synthase (iNOS), TNF-a, cyclooxygenase (COX-2), and interleukin (IL)-1b. In addition, TNB inhibited generation of intracellular reactive oxygen species (ROS). We found that TNB significantly attenuated the nuclear translocation of NF-kB, inhibiting the activation of c-jun N-terminal kinase (JNK) in LPS-stimulated BV-2 cells. Furthermore, TNB reduced cytotoxicity of activated microglia toward HT-22 hippocampal cells in a co-culture system. Taken together, our experimental results reveal, for the first time, that TNB is a potent inhibitor of microglia-mediated inflammation, and it might be a potential candidate for the treatment of neurodegenerative diseases.

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Section: Introductionmentioning

confidence: 99%

1-O-Tigloyl-1-O-deacetyl-nimbolinin B Inhibits LPS-Stimulated Inflammatory Responses by Suppressing NF-κB and JNK Activation in Microglia Cells

et al. 2014

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“…The presence of two acetate groups was indicated by signals at d H 1.99 (3H, s) and 2.08 (3H, s). A comparison of the NMR spectra of 1 and the reported compound meliatoosenin I (2) (Zhang et al, 2012) showed that they had similar skeletons, except for the ester moiety at C-29. C-29 in 2 was attached to 2-methylbutanoyl, whereas 1 had a methylpropionyl group at this position.…”

Section: Resultsmentioning

confidence: 94%

“…The other isolated compounds were identified as meliatoosenin I (2) (Zhang et al, 2012), 29-deacetylsendanin (3, C-29 epimeric mixture, 1:1) (Itokawa et al, 1995), trichillin H (4) , 12-O-acetylazedarachin B (5) , meliatoxin A 1 (6) (Macleod et al, 1990;Oelrichs et al, 1983), meliatoxin B 2 (7) (Macleod et al, 1990;Oelrichs et al, 1983) and meliatoxin B 1 (8) (Macleod et al, 1990;Oelrichs et al, 1983).…”

Section: Resultsmentioning

confidence: 99%

Limonoids with Wnt signal inhibitory activity isolated from the fruits of Azadirachta excelsa

Fuentes

Toume

Arai

et al. 2015

Phytochemistry Letters

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“…The fruits of M. toosendan ("Chuan-Lian-Zi" in Chinese) is a traditional Chinese medicine (TCM) recorded in Pharmacopoeia of China and has been used as an antiparasitic and analgesic agent [1][2][3]. Previous phytochemical studies on different parts of M. toosendan have led to reports of a series of highly functionalized limonoids, euphane-and tirucallane-type triterpenoids, steroids and lignans [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The lipophilic phytochemicals of this species have been extensively investigated in recent years, while the hydrophilic constituents were rarely reported [21].…”

Section: Introductionmentioning

confidence: 99%