Endowing machines with sensing capabilities similar to those of humans is a prevalent quest in engineering and computer science. In the pursuit of making computers sense their surroundings, a huge effort has been conducted to allow machines and computers to acquire, process, analyze and understand their environment in a human-like way. Focusing on the sense of hearing, the ability of computers to sense their acoustic environment as humans do goes by the name of machine hearing. To achieve this ambitious aim, the representation of the audio signal is of paramount importance. In this paper, we present an up-to-date review of the most relevant audio feature extraction techniques developed to analyze the most usual audio signals: speech, music and environmental sounds. Besides revisiting classic approaches for completeness, we include the latest advances in the field based on new domains of analysis together with novel bio-inspired proposals. These approaches are described following a taxonomy that organizes them according to their physical or perceptual basis, being subsequently divided depending on the domain of computation (time, frequency, wavelet, image-based, cepstral, or other domains). The description of the approaches is accompanied with recent examples of their application to machine hearing related problems.

Abstract:The Environmental Noise Directive (END) requires that regular updating of noise maps is implemented every five years to check and report about the changes occurred during the reference period. The updating process is usually achieved using a standardized approach, consisting in collating and processing information through acoustic models to produce the updated maps. This procedure is time consuming and costly, and has a significant impact on the budget of the authorities responsible for providing the maps. Furthermore, END requires that simplified and easy-to-read noise maps are made available to inform the public about noise levels and actions to be undertaken by local and central authorities to reduce noise impacts. To make the updating of noise maps easier and more cost effective, there is a need for integrated systems that incorporate real-time measurement and processing to assess the acoustic impact of noise sources. To that end, a dedicated project, named DYNAMAP (DYNamic Acoustic MAPping), has been proposed and co-financed in the framework of the LIFE 2013 program, with the aim to develop a dynamic noise mapping system able to detect and represent in real time the acoustic impact of road infrastructures. In this paper, after a comprehensive description of the project idea, objectives and expected results, the most important steps to achieve the ultimate goal are described.

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Trisomy of human chromosome 21 (Down syndrome, DS) alters development of multiple organ systems, including the face and underlying skeleton. Besides causing stigmata, these facial dysmorphologies can impair vital functions such as hearing, breathing, mastication, and health. To investigate the therapeutic potential of green tea extracts containing epigallocatechin-3-gallate (GTE-EGCG) for alleviating facial dysmorphologies associated with DS, we performed an experimental study with continued pre- and postnatal treatment with two doses of GTE-EGCG supplementation in a mouse model of DS, and an observational study of children with DS whose parents administered EGCG as a green tea supplement. We evaluated the effect of high (100 mg/kg/day) or low doses (30 mg/kg/day) of GTE-EGCG, administered from embryonic day 9 to post-natal day 29, on the facial skeletal development in the Ts65Dn mouse model. In a cross-sectional observational study, we assessed the facial shape in DS and evaluated the effects of self-medication with green tea extracts in children from 0 to 18 years old. The main outcomes are 3D quantitative morphometric measures of the face, acquired either with micro-computed tomography (animal study) or photogrammetry (human study). The lowest experimentally tested GTE-EGCG dose improved the facial skeleton morphology in a mouse model of DS. In humans, GTE-EGCG supplementation was associated with reduced facial dysmorphology in children with DS when treatment was administered during the first 3 years of life. However, higher GTE-EGCG dosing disrupted normal development and increased facial dysmorphology in both trisomic and euploid mice. We conclude that GTE-EGCG modulates facial development with dose-dependent effects. Considering the potentially detrimental effects observed in mice, the therapeutic relevance of controlled GTE-EGCG administration towards reducing facial dysmorphology in young children with Down syndrome has yet to be confirmed by clinical studies.

Summary Root analysis is essential for both academic and agricultural research. Despite the great advances in root phenotyping and imaging, calculating root length is still performed manually and involves considerable amounts of labor and time. To overcome these limitations, we developed MyROOT, a software for the semiautomatic quantification of root growth of seedlings growing directly on agar plates. Our method automatically determines the scale from the image of the plate, and subsequently measures the root length of the individual plants. To this aim, MyROOT combines a bottom‐up root tracking approach with a hypocotyl detection algorithm. At the same time as providing accurate root measurements, MyROOT also significantly minimizes the user intervention required during the process. Using Arabidopsis, we tested MyROOT with seedlings from different growth stages and experimental conditions. When comparing the data obtained from this software with that of manual root measurements, we found a high correlation between both methods (R2 = 0.997). When compared with previous developed software with similar features (BRAT and EZ‐Rhizo), MyROOT offered an improved accuracy for root length measurements. Therefore, MyROOT will be of great use to the plant science community by permitting high‐throughput root length measurements while saving both labor and time.

SummaryTelomeres are specialized nucleoprotein caps that protect chromosome ends assuring cell division. Single-cell telomere quantification in animals established a critical role for telomerase in stem cells, yet, in plants, telomere-length quantification has been reported only at the organ level. Here, a quantitative analysis of telomere length of single cells in Arabidopsis root apex uncovered a heterogeneous telomere-length distribution of different cell lineages showing the longest telomeres at the stem cells. The defects in meristem and stem cell renewal observed in tert mutants demonstrate that telomere lengthening by TERT sets a replicative limit in the root meristem. Conversely, the long telomeres of the columella cells and the premature stem cell differentiation plt1,2 mutants suggest that differentiation can prevent telomere erosion. Overall, our results indicate that telomere dynamics are coupled to meristem activity and continuous growth, disclosing a critical association between telomere length, stem cell function, and the extended lifespan of plants.

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