DXA-Based 3D Analysis of the Cortical and Trabecular Bone of Hip Fracture Postmenopausal Women: A Case-Control Study

Humbert, Ludovic; Bagué, Alexis; Gregorio, Silvana Di; Winzenrieth, Renaud; Sevillano, Xavier; Ballester, Miguel Ángel González; Río, Luis Del

doi:10.1016/j.jocd.2018.11.004

Cited by 13 publications

(15 citation statements)

References 28 publications

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“…This method used a statistical 3D model of the proximal femur’s form and density, and was built from the quantitative computed tomography (QCT) database (Caucasian men and women). The details of this method’s modeling can be found in Winzenrieth et al and Humbert et al [ 12 , 13 ]. The study was made from DXA exploration in order to obtain a 3D model specific to the patient’s proximal femur, generating measurements in 3D from the total area of interest in the femur.…”

Section: Methodsmentioning

confidence: 99%

“…The cortical thickness (Cth, mm) and BMD of the cortical surface (sBMD cortical, mg/cm 2 , obtained by the multiplication of cortical vBMD (mg/cm 3 ) and Cth (cm)) provided additional analysis for the cortical region. The models and 3D-SHAPER measurements’ precision were evaluated against a QCT [ 12 , 13 ]. The average form precision—i.e., the average distance between external limits of the femur geometry—were derived from 3D-SHAPER and QCT, and the result was 0.93 mm.…”

Section: Methodsmentioning

confidence: 99%

“…The average form precision—i.e., the average distance between external limits of the femur geometry—were derived from 3D-SHAPER and QCT, and the result was 0.93 mm. Regarding bone density and cortical bone thickness, the correlation coefficients between 3D-SHAPER and the measurements derived from QCT were 0.86, 0.93, and 0.91 for trabecular vBMD, cortical vBMD, and cortical thickness, respectively [ 12 , 13 ].…”

Section: Methodsmentioning

confidence: 99%

“…Three-dimensional (3D) densitometry permits an assessment of the shape and intrinsic material properties that determine bone strength. Hip DXA is transformed using segmentation algorithms to provide a 3D analysis of the cortical and trabecular compartments [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Relationship between Insulin Resistance (HOMA-IR), Trabecular Bone Score (TBS), and Three-Dimensional Dual-Energy X-ray Absorptiometry (3D-DXA) in Non-Diabetic Postmenopausal Women

Campillo-Sánchez

Usategui-Martín

Temiño

et al. 2020

JCM

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Background: Insulin may play a key role in bone metabolism, where the anabolic effect predominates. This study aims to analyze the relationship between insulin resistance and bone quality using the trabecular bone score (TBS) and three-dimensional dual-energy X-ray absorptiometry (3D-DXA) in non-diabetic postmenopausal women by determining cortical and trabecular compartments. Methods: A cross-sectional study was conducted in non-diabetic postmenopausal women with suspected or diagnosed osteoporosis. The inclusion criteria were no menstruation for more than 12 months and low bone mass or osteoporosis as defined by DXA. Glucose was calculated using a Hitachi 917 auto-analyzer. Insulin was determined using an enzyme-linked immunosorbent assay (EIA). Insulin resistance was estimated using a homeostasis model assessment of insulin resistance (HOMA-IR). DXA, 3D-DXA, and TBS were thus collected. Moreover, we examined bone parameters according to quartile of insulin, hemoglobin A1C (HbA1c), and HOMA-IR. Results: In this study, we included 381 postmenopausal women. Women located in quartile 4 (Q4) of HOMA-IR had higher values of volumetric bone mineral density (vBMD) but not TBS. The increase was higher in the trabecular compartment (16.4%) than in the cortical compartment (6.4%). Similar results were obtained for insulin. Analysis of the quartiles by HbA1c showed no differences in densitometry values, however women in Q4 had lower levels of TBS. After adjusting for BMI, statistical significance was maintained for TBS, insulin, HOMA-IR, and HbA1c. Conclusions: In non-diabetic postmenopausal women there was a direct relationship between insulin resistance and vBMD, whose effect is directly related to greater weight. TBS had an inverse relationship with HbA1c, insulin, and insulin resistance unrelated to weight. This might be explained by the formation of advanced glycosylation products (AGEs) in the bone matrix, which reduces bone deformation capacity and resistance, as well as increases fragility.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Relationship between Insulin Resistance (HOMA-IR), Trabecular Bone Score (TBS), and Three-Dimensional Dual-Energy X-ray Absorptiometry (3D-DXA) in Non-Diabetic Postmenopausal Women

Campillo-Sánchez

Usategui-Martín

Temiño

et al. 2020

JCM

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“…These results suggest that bone architecture studies could be of special interest with other diseases involving high bone remodeling. However, Humbert et al 20 observed a non-significant decrease in cortical thickness in postmenopausal patients with hip fracture compared to controls (1.746±0.127 mm vs. 1.783±0.123 mm; p=0.1). In our study, patients with HPP and traumatic fracture did not show a decrease in cortical thickness compared to those who did not fracture.…”

Section: Originalsmentioning

confidence: 93%

Evaluación de la densidad mineral ósea y de los parámetros de 3D-Shaper en la hipofosfatasia congénita del adulto

Tornero

Coronado

Humbert³

et al. 2020

Rev Osteoporos Metab Miner

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Objetive: To evaluate bone mineral density (BMD) and 3D-Shaper parameters at the proximal femur (FP) level in adults with genetically confirmed hypophosphatasia (HPP) and to compare them in those subjects with and without fractures. Material and methods: Cross-sectional analysis of densitometric data and bone architecture from the baseline visit of a longitudinal study in which patients with HPP were included. A densitometric study (Lunar Prodigy, GE iDXA) was carried out in FP using 3D-Shaper software (version 2.7. Galgo Medical). Results: 33 adults with HPP with heterozygous mutations were included. 63.6% (21/33) were women (42.9% postmenopausal), and 8 of the men (66.6%) were older than 50 years. The mean age was 50.56±15.08 years, 30.3% (10/33) had previous traumatic fractures and 15.2% (5/33) presented stress fractures. The prevalence of osteoporosis in CF was 11.8% (2/17) and of osteopenia, 82.4% (14/17). In premenopausal women and young men, low bone mass was detected for age in 12.5% (2/16). When comparing subjects with and without stress fractures, as well as traumatic ones, there were no differences in BMD. The 3D-Shaper showed a decrease in cortical thickness (mm) in patients with stress fractures [1.8 (1.77-1.89)] compared to subjects without them [1.94 (1.87-2.03, p=0.03)] and compared to those with traumatic fractures [1.97 (1.88-2.04), p=0.03]. Conclusions: These data reflect a discrete densitometric impact in milder forms of the adult. Bone architecture studies could be of interest in determining patients susceptible to stress fractures.

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3D analysis of bone mineral density in a cohort: age- and sex-related differences

Valero

Olmos

Humbert³

et al. 2021

Arch Osteoporos

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Abbreviations aBMD-FN: Areal bone mineral density at femoral neck in grams per square centimeter aBMD-TH: Areal bone mineral density at total femur in grams per square centimeter Trabecular vBMD: Trabecular volumetric bone mineral density in milligrams per cubic centimeter Integral vBMD: Integral volumetric bone mineral density in milligrams per cubic centimeter Cortical sBMD: Cortical surface bone mineral density in milligrams per square centimeter Manuscript Click here to access/download;Manuscript;DXA 3D CAMARGO2021corregido (2).docx Click here to view linked References

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DXA-Based 3D Analysis of the Cortical and Trabecular Bone of Hip Fracture Postmenopausal Women: A Case-Control Study

Cited by 13 publications

References 28 publications

Relationship between Insulin Resistance (HOMA-IR), Trabecular Bone Score (TBS), and Three-Dimensional Dual-Energy X-ray Absorptiometry (3D-DXA) in Non-Diabetic Postmenopausal Women

Relationship between Insulin Resistance (HOMA-IR), Trabecular Bone Score (TBS), and Three-Dimensional Dual-Energy X-ray Absorptiometry (3D-DXA) in Non-Diabetic Postmenopausal Women

Evaluación de la densidad mineral ósea y de los parámetros de 3D-Shaper en la hipofosfatasia congénita del adulto

3D analysis of bone mineral density in a cohort: age- and sex-related differences

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