Pentraxin-3 (PTX-3) is one of the newly discovered tumor biomarker, especially in the diagnosis of lung cancer. The functionalized multi-walled carbon nanotubes (MWCNTs) and gold nanowires (AuNWs) nanocomposites decorated the PTX-3 biosensor were reported in this work, realizing ultrasensitive detection of PTX-3 in human serum through simple and effective non-enzymatic reaction. The PTX-3 biosensor has excellent electrochemical activity and biocompatibility through carbon and metal nanomaterials. Compared with pure MWCNTs, the MWCNTs combined with AuNWs which shows a wide range of detection (0.001–1000 ng ml-1), higher sensitivity (17.10 μA/(ng ml-1)/cm2) and lower detection limits (0.16 pg ml-1, S/N = 3). Meanwhile, gold nanomaterials are one of the most stable noble metal nanomaterials and MWCNTs possess large electroactive surface area, which can greatly improves the stability (96.3%, after 3 weeks) and repeatability (RSD = 0.51%). This work remarkably extends the utilization of MWCNTs and AuNWs in the construction of biosensors in the fields of biosensing and medical diagnosis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.