We consider the problem of spectrum sharing in a cognitive radio system consisting of a primary user and a secondary user. The primary user and the secondary user work in a non-cooperative manner. Specifically, the primary user is assumed to update its transmit power based on a pre-defined power control policy. The secondary user does not have any knowledge about the primary user's transmit power, or its power control strategy. The objective of this paper is to develop a learning-based power control method for the secondary user in order to share the common spectrum with the primary user. To assist the secondary user, a set of sensor nodes are spatially deployed to collect the received signal strength information at different locations in the wireless environment. We develop a deep reinforcement learning-based method, which the secondary user can use to intelligently adjust its transmit power such that after a few rounds of interaction with the primary user, both users can transmit their own data successfully with required qualities of service. Our experimental results show that the secondary user can interact with the primary user efficiently to reach a goal state (defined as a state in which both users can successfully transmit their data) from any initial states within a few number of steps.

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Chondrosarcoma is a type of malignant bone tumor secreting cartilage-like matrix. In clinical treatment, there is no frequently used drug treatment option except for surgical resection. Hedgehog (HH) pathway is a classical signaling pathway that regulates normal cartilage cell development. In order to detect the role that HH pathway plays in chondrosarcoma, we used immunohistochemistry and found this tumor clearly expressed HH pathway-related proteins. Treatment with HH pathway inhibitor-4 (HPI-4) could significantly decrease human chondrosarcoma cell proliferation, invasion and migration ability. Furthermore, HPI-4 could distinctly disturb HH pathway-mediated ciliogenesis and suppress primary cilia-related protein intraflagellar transport protein IFT88 expression. HH downstream effect molecular GLI2 was restrained to block parathyroid hormone-related protein and affect MAPK/ERK-regulated matrix metalloproteinases (MMP2 and MMP9). These results indicated that activated HH pathway existed in chondrosarcoma and HPI-4 could be a new therapeutic option specific to chondrosarcoma expressing elevated levels of HH pathway.

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The natural product neocarzilin A ( NCA ) was discovered decades ago, and despite its potent cytotoxic effects no mode of action studies have been performed up to date. Synthesis of neocarzilins A, B, and C and a stereoisomer of NCA provided insights into structural preferences as well as access to probes for functional studies. NCA turned out to be the most active member and was not only effective against cell proliferation but also migration, a novel and so far overlooked activity. To decipher the molecular mode of action, we applied chemical proteomics for target discovery and revealed that NCA targets cancer cell migration via irreversible binding to the largely uncharacterized synaptic vesicle membrane protein VAT-1. A corresponding knockout of the protein confirmed the phenotype, and pull-down studies showed the interaction with an intricate network of key migration mediators such as Talin-1. Overall, we introduce VAT-1 as a promising novel target for the development of selective migration inhibitors with the perspective to limit toxicity in the absence of antiproliferative effects.

Offshore wave energy can be easily predicted and is proved to be much better than other forms of ocean energy such as shoreline wave, near-shore wave, and tides. Research on offshore wave energy extraction has been carried out in many countries to meet the growing demand for clean energy and reduce the impact on natural environment. This paper reviews the development of offshore wave energy extraction systems in the recent decade. Several aspects are introduced, including a global wave energy resource assessment, offshore wave energy extraction technologies, and the interaction between wave and floating buoy as well as linear generators. Although various offshore wave energy extraction systems have been proposed and even tested, it is difficult to decide which is the best one. In fact, design of floating buoy and linear generators plays an important role in the operational efficiency of offshore wave energy extraction system. This review provides some useful guidelines for future studies in this field.

Chondrosarcoma is a bone tumor characterized by the secretion of a cartilage-like extracellular matrix. It has been proved to lack extracellular sensor primary cilia. This study aimed to illustrate a feasible therapeutic method for chondrosarcoma by regulating primary cilia assembly through inhibiting histone deacetylases 6 (HDAC6) activation. In order to detect the interaction between primary cilia and HDAC6 in human chondrosarcoma, Tubastatin A and small interfering RNA (siRNA) were used to inhibit the endogenous expression of HDAC6. Cell viability test and Transwell assay were applied to evaluate the effects of malignant biological properties. Primary cilia staining and related proteins were detected. The abnormal expression of HDAC6 and cilia intraflagellar transport protein 88 (IFT88) was found in chondrosarcoma tissues. The inhibition of HDAC6 could downregulate the proliferation of chondrosarcoma cells in a concentration- and time-dependent manner and suppress the invasion capacity of tumor cells. Besides, the downregulation of HDAC6 exhibited a negative effect on the proliferation of relevant proteins but a positive effect on the primary cilia-related expression of IFT88 and acetylated α-tubulin. Primary cilia restoration could be observed after HDAC6 siRNA transfection. The Aurora A-HDAC6 cascade was involved in regulating primary cilia resorption by affecting α-tubulin deacetylation and Tubastatin A could inhibit chondrosarcoma cell growth in vivo. These results indicate that restricting HDAC6 can restore primary cilia assembly accompanied with suppressed chondrosarcoma cell proliferation and invasion capacities. Thus, promoting primary cilia restoration by targeting HDAC6 may be a feasible potential therapeutic method for chondro-sarcoma treatment.

We established a 3D coupled model to study the electromagnetic-thermal behaviors of a levitation system containing a bulk high-temperature superconductor (HTS) with a cuboid slot under the nonuniform magnetic field due to the movement of a permanent magnet (PM), analysing the influences of the geometrical parameters of the slot and inclination angle on the electromagnetic-thermal behaviors, giving the dynamic distribution of the global electromagnetic force density in the HTS. The results show that the longer the length of the slot, the smaller the levitation force, and the greater the loss. As its length takes up 7/10 of the HTS diameter, the loss is 4 times that of the HTS without damage. Due to the homodromous induced current appearing near the slot, the maximum guidance force increases with the length. The levitation force decreases with the increase of the slot depth. Its curve near the maximum becomes blunt and the loss increases significantly. As the depth is 3/5-4/5 of the HTS height, the loss is 300-400 times of that without damage. The guidance force and loss increase with the depth. As the inclination angle rises, the levitation and guidance force both drop. At 30 • , their maximums decrease by 70 % and 90 %, respectively. The lateral stability of the system thus becomes poorer, indicating the inclination angle is one of the important factors for instability. As the PM moves vertically, the guidance force density symmetrically distributes near the both wide sides of the slot. Its side faces with the wide sides will bear the shear force, resulting in that the slot has the tendency to tear along these faces. As the PM reciprocates laterally, the slot is subjected to the lateral shear force, proportional to the displacement.