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Low-Density Lipoprotein (LDL)-Antioxidant Lignans from Myristica fragransSeeds. -The bioactivity-guided fractionation of the methanol extracts of M.fragans seeds leads to the isolation of six compounds that are identified as five diarylbutane lignans and one aryltetralin lignan. Among the diarylbutane lignans, (II) has proven to be a new compound. Due to its potent LDL-antioxidant activity in the TBARS assay, lignan (I) is tested for complementary in vitro investigations such as lag time, relative electrophoretic mobility of ox-LDL, and fragmentation of apoB-100 on copper-mediated LDL oxidation. In macrophage-mediated LDL oxidation, the TBARS formation is also inhibited by (I). -(KWON, H. S.; KIM, M.-J.; JEONG, H. J.; YANG, M. S.; PARK, K. H.; JEONG*, T.-S.; LEE, W. S.; Bioorg. Med.