Antioxidant Effects of Quinoline Alkaloids and 2,4-Di-tert-butylphenol Isolated from Scolopendra subspinipes

Yoon, Mi-Ae; Jeong, Tae‐Sook; Park, Doo-Sang; Xu, Meijuan; Oh, Hyun‐Woo; Song, Kyoung-Bin; Lee, Woo Song; Park, Ho-Yong

doi:10.1248/bpb.29.735

Cited by 111 publications

(67 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Report have shown that 1,2-benzenediol possess antimicrobials as well as antiplatelet 25,26 activity. Phenol, 2,4-bis (1, 1-dimethylethyl)-has also been reported in Scolopendra subspinispes with strong antioxidant activity, 28 Pereskia bleo with anticancer activity, 29 and strain of Pseudomonas monteilii PsF84 with antifungal activity, 30 Additionally, vitamin E identified two times at different retention times in this study is a well known antioxidant compound used for the treatment of various illnesses while N-Acetyl-Alpha-D-glucosamine has been used as safe alternative therapies for osteoarthritis,…”

Section: Discussionmentioning

confidence: 97%

Effects of standardized stem bark extract of Mangifera indica L. in wistar rats with 2,4-dinitrophenylhydrazine-induced haemolytic anaemia

Sani¹,

Malami

Hassan³

et al. 2015

Phcog J

View full text Add to dashboard Cite

Background:The aqueous decoction of the stem back of Mangifera indica L. has been traditionally used for the treatment of various illnesses among them includes anaemia. Aims: The aim of this study was to investigate the anti-anaemic properties of standardized stem bark extract of M. indica in animals with 2,4-dinitrophenylhydrazine-induced haemolytic anaemia. Methods and Material: An in vivo animal model was used in this experiment. 2,4-dinitrophenylhydrazine was used to induce haemolysis and treatment was done with three different concentrations (25, 50, and 100 mg/ kg b.wt) of the plant extract. Astifer® was used as a positive control. Haematological parameters such as PCV, HGb concentration, and TLC were performed and to ascertain the level of haemolysis. GC-MS was used determine the present of phytoconstituents within the crude extract. Results: PCV and HGb concentration increased significantly (p<0.001) at a dose of 50 and 100 mg/kg b.wt respectively while no significant (p>0.05) effect was observed at a dose of 25 mg/kg b.wt. TLC was decreased significantly (p<0.001) at a dose 100 mg/kg b.wt while no significant (p>0.05) effect was observed at a dose of 25 and 50 mg/kg b.wt respectively. GC-MS analysis revealed presence of 15 compounds viz: 2,2-Dimethoxybutane, N-Acetyl-Alpha-D-glucosamine, 1,2-Benzenediol, Phenol, 2,4-bis(1,1-dimethylethyl)-, Vitamin E, Pentadecanoic acid, 13-methyl-, methyl ester, 2-Ethylacridine, Benzofuran-6-ol-3-one, 2-(4ethoxycarbonyl)benzylidene-, 9-Octadecanoic acid, (E)-, 2,4,6-Cycloheptatrien-1-one, 3,5-bis-trimethylsilyl-, and Benzo[h]quinoline,2,4-dimethyl-. Conclusion: The results of our present finding suggest the significant anti-anaemic properties of standardized stem bark extract of Mangefera indica L. This finding highlights the potentials of the extract and M. indica in the treatment of haemolytic anaemia.

show abstract

Section: Discussionmentioning

confidence: 97%

Effects of standardized stem bark extract of Mangifera indica L. in wistar rats with 2,4-dinitrophenylhydrazine-induced haemolytic anaemia

Sani¹,

Malami

Hassan³

et al. 2015

Phcog J

View full text Add to dashboard Cite

show abstract

“…23) According to previous reports, BP is an antioxidant with remarkable cytotoxic activity against cancer cells, 24,25) and it has been shown to decrease the degree of low-density lipoprotein (LDL)-oxidation. 26) Moreover, BP was reported to be the active compound in the ethanol extract of Ipomoea batatas that was shown to be protective against Aβ-induced neurotoxicity. 27) TMT, a potent neurotoxicant, has been used to induce experimental models of AD.…”

Section: Discussionmentioning

confidence: 99%

Cinnamomum loureirii Extract Inhibits Acetylcholinesterase Activity and Ameliorates Trimethyltin-Induced Cognitive Dysfunction in Mice

Kim

Choi

Kwon

et al. 2016

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

The pathogenesis of Alzheimer's disease (AD) has been linked to the deficiency of neurotransmitter acetylcholine (ACh) in the brain, and the main treatment strategy for improving AD symptoms is the inhibition of acetylcholinesterase (AChE) activity. In the present study, we aimed to identify potent AChE inhibitors from Cinnamomum loureirii extract via bioassay-guided fractionation. We demonstrated that the most potent AChE inhibitor present in the C. loureirii extract was 2,4-bis(1,1-dimethylethyl)phenol. To confirm the antiamnesic effects of the ethanol extract of C. loureirii, mice were intraperitoneally injected with the neurotoxin trimethyltin (2.5 mg/kg) to induce cognitive dysfunction, and performance in the Y-maze and passive avoidance tests was assessed. Treatment with C. loureirii extract significantly improved performance in both behavioral tests, suggesting that this extract may be neuroprotective and therefore beneficial in preventing or ameliorating the degenerative processes of AD, potentially by restoring cholinergic function. Key words Alzheimer's disease; Cinnamomum loureirii; acetylcholine; acetylcholinesterase inhibitorThe pathophysiology of Alzheimer's disease (AD), a type of dementia in the elderly, is highly complex. This progressive degenerative disorder was first discovered by Dr. Alois Alzheimer in 1907 and is characterized by incapacitating memory and language losses and impairments in cognitive and behavioral functions. A neuropathological diagnosis of AD includes deposition of extracellular β-amyloid (Aβ) plaques in the cerebral cortex and hippocampus areas, accumulation of intracellular neurofibrillary tangles of abnormally phosphorylated τ, astrocytic gliosis, inflammatory cascades, and degeneration of basal forebrain cholinergic neurons.

show abstract

“…The results show that 2,4-Di-tertbutylphenol, stigmasterol, and campesterol are the major components in the extracts. In many reports, plant extracts containing 2,4-Di-tertbutylphenol were shown to possess antioxidant and neuronal protective effects [8][9][10]. Research has indicated that stigmasterol may be useful in the prevention of certain cancers and possesses potent antioxidant, hypoglycemic and thyroid inhibiting properties [11].…”

Section: Discussionmentioning

confidence: 99%

Chromatographic-mass spectrometric analysis of ethanol extract of Maesa perlaria var formosana

Yang¹,

Liang²,

Yang³

et al. 2016

Trop. J. Pharm Res

View full text Add to dashboard Cite

show abstract

Antioxidant Effects of Quinoline Alkaloids and 2,4-Di-tert-butylphenol Isolated from Scolopendra subspinipes

Cited by 111 publications

References 23 publications

Effects of standardized stem bark extract of Mangifera indica L. in wistar rats with 2,4-dinitrophenylhydrazine-induced haemolytic anaemia

Effects of standardized stem bark extract of Mangifera indica L. in wistar rats with 2,4-dinitrophenylhydrazine-induced haemolytic anaemia

<i>Cinnamomum loureirii</i> Extract Inhibits Acetylcholinesterase Activity and Ameliorates Trimethyltin-Induced Cognitive Dysfunction in Mice

Chromatographic-mass spectrometric analysis of ethanol extract of <i>Maesa perlaria</i> var <i>formosana</i>

Contact Info

Product

Resources

About