The finite-temperature magnetic properties of Fe x Pd 1−x and Co x Pt 1−x alloys have been investigated. It is shown that the temperature-dependent magnetic behaviour of alloys, composed of originally magnetic and non-magnetic elements, cannot be described properly unless the coupling between magnetic moments at magnetic atoms (Fe,Co) mediated through the interactions with induced magnetic moments of non-magnetic atoms (Pd,Pt) is included. A scheme for the calculation of the Curie temperature (T C ) for this type of systems is presented which is based on the extended Heisenberg Hamiltonian with the appropriate exchange parameters J ij obtained from ab-initio electronic structure calculations. Within the present study the KKR Green's function method has been used to calculate the J ij parameters. A comparison of the obtained Curie temperatures for Fe x Pd 1−x and Co x Pt 1−x alloys with experimental data shows rather good agreement.
The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra are described. The most active compounds in this test, N-methyl-3-chlorobenzylamine (19, MIC 10.2 micrograms/mL), N-methyl-3,5-dichlorobenzylamine (93, MIC 10.2 micrograms/mL), and N-butyl-3,5-difluorobenzylamine (103, MIC 6.4 micrograms/mL), also exhibited a marked inhibitory effect on Mycobacterium marinum and Mycobacterium lufu used for the determination of antileprotic properties. The combinations of 93 with aminosalicylic acid, streptomycin, or dapsone exert marked supra-additive effects on M. tuberculosis H 37 Ra.
Amphiphilic drugs of various structures are known to interact with phospholipids. Simple benzylamines have been used as probes to test the structural influence on the degree of interaction. This interaction has been quantified with various methods as for example NMR‐binding measurements, scanning calorimetry, inhibition of Ca++‐incorporation, negative inotropic effect and antimycobacterial activity.
Multiregression and multivariate data analysis have been performed and the results are discussed.
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