Two degenerative diseases of the central nervous system of man, kuru and Creutzfeldt-Jakob disease, were transmitted to marmoset monkeys. Kuru was passed serially, with decrease in the latent periods.
Plasma samples from 12 gorillas, six orang-utans and five chimpanzees
were evaluated for antibodies against viral, rickettsial, chlamydial or mycoplasmal antigens,
and circulating lymphocyte subpopulations were characterized by assay of surface
markers.
Antibodies that cross-reacted with the viral capsid antigen of Epstein-Barr virus were
present in all 23 animals. Antibodies against the following agents were detected in > 25%
of animals by species: hepatitis A virus (gorillas, orang-utans, chimpanzees); hepatitis B
virus - HBs, HBc, HBe (chimpanzees); rubeola virus (gorillas, orang-utans); rubella virus
(gorillas, orang-utans); mumps V antigen (gorillas); herpes simplex virus (gorillas); Coxiella
burnetii (orang-utans). Percentages of circulating T and B lymphocytes were similar for all
three species and approximated the levels observed in human peripheral lymphocyte populations.
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