Biological Studies with Viral Induced Fibrosarcomas in Cats, Dogs, Rabbits and Non-human Primates

Gh, Theilen; Sp, Synder; Lg, Wolfe; Jc, Landon

doi:10.1159/000391731

Cited by 7 publications

(6 citation statements)

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“…Marmosets less than 2 months old were highly susceptible to 104 FFU of FSV, more so than any other nonhuman primate tested [62]. Multiple intra-abdominal tumors developed in animals inoculated i.p., and local tumors developed following i.m.…”

Section: B Feline Sarcoma Virus (Fsv)mentioning

confidence: 97%

“…The suscepti bility of the primates used in these studies was usually dependent upon the use of immunosuppressive therapy, and even with its use, most of the tumors regressed spontaneously. More recently, Rous sarcoma virus was also shown to induce tumors in M. mulatta after intracerebral inoculation [33] and in Saimiri sciureus, Galago crassicaudatus and African green monkeys, but again most of the tumors spontaneously regressed [33,38,67], Another oncogenic C-type virus, feline fibrosarcoma virus, also has induced tumors in Saimiri sciureus [51] and in M. radiata, M. mulatta and M. fascicu/aris [62] but these tumors, like the Rous sarcoma virusal-induced tumors, regressed spon taneously. Yaba virus, a simian DNA virus, has induced histiocytomas in nonhurnan primates both under natural and experimental conditions, which also usually regressed [4.…”

Section: White-lipped Marmosets (Saguinus Nigricollis and Subspecies mentioning

confidence: 99%

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Induction of Neoplasms by Viruses in Marmoset Monkeys

Deinhardt¹,

Wolfe²,

Northrop³

et al. 1972

J Med Primatol

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C-type RNA viruses of avian, feline and simian origin induce sarcomas in marmosets and a simian herpesvirus induces lymphomas and/or lymphocytic leukemias. Virus genome expression is usually repressed to various degrees in vivo, but becomes derepressed if the tumor cells are grown in vitro. The high susceptibility of marmosets to oncogenic viruses and the hematopoietic chimerism between offspring make them ideal animals for studying not only the oncogenic activity of animal tumor viruses and of potentially oncogenic materials but also the immune response to the viral-induced neoplastic diseases.

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Section: B Feline Sarcoma Virus (Fsv)mentioning

confidence: 97%

Section: White-lipped Marmosets (Saguinus Nigricollis and Subspecies mentioning

confidence: 99%

Induction of Neoplasms by Viruses in Marmoset Monkeys

Deinhardt¹,

Wolfe²,

Northrop³

et al. 1972

J Med Primatol

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“…The ability of the FeSV system to induce tumours in heterospecies as diverse as dogs, rabbits and monkeys (Snyder and Theilen, 1969;Theilen et al, 1969;Deinhardt et al, 1970) and, more recently, in sheep (Theilen, 1971;Theilen et al, 1974) and rats (Maruyama, Wagner and Domchowski, 1973) (Essex, 1974;Jarrett, 1975) seemed that the serological responses were directed principally against virus material that had become incorporated in the cell membrane (Hardy et al, 1969;Sibal et al, 1970;Riggs, 1971;Riggs et al, 1973).…”

Section: Discussionmentioning

confidence: 99%

Studies on FeSV induced sarcomata in sheep with particular reference to the regional lymphatic system

Jg¹,

Scollay²,

Birbeck³

et al. 1975

Br J Cancer

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Summary.-Inocula of cultured sheep cells that had been transformed with FeSV were injected into the legs of sheep so that the changes in the cellular and humoral composition of the efferent lymph from the regional node could be studied throughout the immune responses. The times at which immunoblasts and specific antibodies appeared in the lymph were similar to those recorded during responses to conventional antigens. The antibodies were mainly 7S, Gl immunoglobulins directed against virion antigens on the membranes of the transformed cells.Larger doses of transformed cells were injected into 12 sheep so that 4 of them developed locally invasive, poorly differentiated fibrosarcomata. Two tumours regressed spontaneously; 2 grew progressively and one of these gave rise to regional metastases. The progressive tumours were not infiltrated with host cells and grew in the presence of high titres of antibody. The tumours that regressed were infiltrated heavily with round cells and detectable antibody was low or absent.The flow and composition of peripheral lymph coming from the tumours showed that the failure of the host to control tumour growth could not be accounted for by a failure of the tumour capillaries to allow the normal transmigration of host cells and humoral factors.

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“…Leukemia in cats and dogs [38,41,50,62] and sarcoma in several species [10,22,58,64] have beenexperimentally induced with cell-free extracts of feline origin in numerous laboratories. The virus particles which cause these tu mors have been identified with electron microscopy as C-type viruses, 110 to 115 mU in diameter, that bud from the plasma or vacuolar cell membranes [36,42,43,62] and have a buoyant density of 1.14-1.17 g/cm3 [40,41].…”

Section: Feline Leukemia and Sarcoma Virusesmentioning

confidence: 99%

“…FeLV will induce leukemia in cats and dogs [38,41,50,62], and feline sar coma virus (FSV) will induce sarcoma in cats, dogs, rabbits, and several types of monkeys [10,22,58,64]. The list is expected to grow longer as other species of domestic and laboratory animals are tested for susceptibility.…”

Section: Feline Leukemia and Sarcoma Virusesmentioning

confidence: 99%

Can Feline Oncornaviruses Cause Leukemia in Man?

Essex¹

1972

Oncology

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Evidence is examined relative to the possibility that feline oncornaviruses can play a role in the induction of some lymphoreticular neoplasms in man, and a hypothesis is presented to suggest how this can occur. Points that implicate the feline oncornaviruses in this way are: (1) many domestic cats in their natural environment excrete FeLV; (2) feline oncornaviruses will induce tumors in several species, including subhuman primates; (3) field strains of FeLV will replicate in human cells; (4) FSV will transform human cells; (5) immunologic depression can greatly interfere with in vivo virus neutralization; (6) immunologic depression greatly enhances the development of spontaneous lymphoreticular neoplasms and those induced in animals with oncornaviruses, and (7) children represent the age group most likely to be exposed to FeLV and to undergo temporary periods of immune depression due to exposure to the common childhood viral diseases and viral vaccines.

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Biological Studies with Viral Induced Fibrosarcomas in Cats, Dogs, Rabbits and Non-human Primates

Cited by 7 publications

References 0 publications

Induction of Neoplasms by Viruses in Marmoset Monkeys

Induction of Neoplasms by Viruses in Marmoset Monkeys

Studies on FeSV induced sarcomata in sheep with particular reference to the regional lymphatic system

Can Feline Oncornaviruses Cause Leukemia in Man?

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