Background Understanding the epidemiological parameters that determine the transmission dynamics of COVID-19 is essential for public health intervention. Globally, a number of studies were conducted to estimate the average serial interval and incubation period of COVID-19. Combining findings of existing studies that estimate the average serial interval and incubation period of COVID-19 significantly improves the quality of evidence. Hence, this study aimed to determine the overall average serial interval and incubation period of COVID-19. Methods We followed the PRISMA checklist to present this study. A comprehensive search strategy was carried out from international electronic databases (Google Scholar, PubMed, Science Direct, Web of Science, CINAHL, and Cochrane Library) by two experienced reviewers (MAA and DBK) authors between the 1st of June and the 31st of July 2020. All observational studies either reporting the serial interval or incubation period in persons diagnosed with COVID-19 were included in this study. Heterogeneity across studies was assessed using the I2 and Higgins test. The NOS adapted for cross-sectional studies was used to evaluate the quality of studies. A random effect Meta-analysis was employed to determine the pooled estimate with 95% (CI). Microsoft Excel was used for data extraction and R software was used for analysis. Results We combined a total of 23 studies to estimate the overall mean serial interval of COVID-19. The mean serial interval of COVID-19 ranged from 4. 2 to 7.5 days. Our meta-analysis showed that the weighted pooled mean serial interval of COVID-19 was 5.2 (95%CI: 4.9–5.5) days. Additionally, to pool the mean incubation period of COVID-19, we included 14 articles. The mean incubation period of COVID-19 also ranged from 4.8 to 9 days. Accordingly, the weighted pooled mean incubation period of COVID-19 was 6.5 (95%CI: 5.9–7.1) days. Conclusions This systematic review and meta-analysis showed that the weighted pooled mean serial interval and incubation period of COVID-19 were 5.2, and 6.5 days, respectively. In this study, the average serial interval of COVID-19 is shorter than the average incubation period, which suggests that substantial numbers of COVID-19 cases will be attributed to presymptomatic transmission.

Background Delay in the diagnosis of Tuberculosis (TB) remains a major challenge against achieving effective TB prevention and control. Though a number of studies with inconsistent findings were conducted in Ethiopia; unavailability of a nationwide study determining the median time of patient delays to TB diagnosis is an important research gap. Therefore, this study aimed to determine the pooled median time of the patient delay to TB diagnosis and its determinants in Ethiopia. Methods We followed PRISMA checklist to present this study. We searched from Google Scholar, PubMed, Science Direct, Web of Science, CINAHL, and Cochrane Library databases for studies. The comprehensive search for relevant studies was done by two of the authors (MA and LY) up to the 10th of October 2019. Risk of bias was assessed using the Newcastle-Ottawa scale adapted for observational studies. Data were pooled and a random effect meta-analysis model was fitted to provide the overall median time of patient delay and its determinants in Ethiopia. Furthermore, subgroup analyses were conducted to investigate how the median time of patient delay varies across different groups of studies. Results Twenty-four studies that satisfied the eligibility criteria were included. Our meta-analysis showed that the median time of the patient delay was 24.6 (95%CI: 20.8–28.4) days. Living in rural area (OR: 2.19, 95%CI: 1.51–3.18), and poor knowledge about TB (OR: 2.85, 95%CI: 1.49–5.47) were more likely to lead to prolonged delay. Patients who consult non-formal health providers (OR: 5.08, 95%CI: 1.56–16.59) had a prolonged delay in the diagnosis of TB. Moreover, the narrative review of this study showed that age, educational level, financial burden and distance travel to reach the nearest health facility were significantly associated with a patient delay in the diagnosis of TB. Conclusions In conclusion, patients are delayed more-than three weeks in the diagnosis of TB. Lack of awareness about TB, consulting non-formal health provider, and being in the rural area had increased patient delay to TB diagnosis. Increasing public awareness about TB, particularly in rural and disadvantaged areas could help to early diagnosis of TB.

BackgroundGlobally, work related injury has been continued as a major public health problem. In Ethiopia there are few fragmented empirical studies particularly among workers of fast growing sectors and there is no a national representative study on work related injury. Therefore, this study aims to determine the magnitude of occupational injury and to identify its predictors among construction, textile and municipal solid waste management workers in Ethiopia.Objectiveto determine magnitude of Work related injury and its disparity across selected occupations in EthiopiaMethod:Both published and unpublished articles conducted in Ethiopia on work related injury were searched between the periods 12 October, 2019 to 15 December, 2019. Random effect model was employed to estimate the overall magnitude of occupational injury and its predictors.ResultsThe overall magnitude of work related injury was 39.35% (95% CI: 27.40, 51.30%). Subgroup analysis revealed that there was slight disparity across occupations and regions. Drinking alcohol, smoking cigarette, khat chewing habit, work related stress, level of education and utilization of PPE were significantly associated with work related injury.ConclusionThis study found that more than 1 in 3 workers had at least one occupational injury at work. There was slight disparity across occupations and regions. It is strongly recommend that health education programs about the risk of substance use on occupational injury and apply strict occupational safety practices regulations should be strengthened.

ObjectivesThe main objective of this study was to assess the roles of traditional healers and the challenges they face in the of prevention and control of both local disease outbreaks and the COVID-19 pandemic, with a special emphasis on the work of traditional healers and healing centers in the East Gojjam Zone in northwestern Ethiopia, between 2020 and 2021.MethodsFrom 25 February 2021 to 2 May 2021, a mixed-methods study (qualitative techniques combined with a quantitative approach) was carried out. The study was conducted by traditional healers and at healing centers in the East Gojjam Zone. The quantitative sample size was calculated based on the assumption of a single population proportion formula. As part of the qualitative research, levels of data saturation were continuously monitored, and were used to determine what the maximum number of study participants should be. Traditional healers and their clients were the study units for the quantitative component, whereas traditional healthcare providers (of all types) and religious leaders were purposively selected as the study units for the qualitative part. Descriptive and inferential statistical methods of analysis, and narrative- and content-wise methods of analysis, were used for the quantitative and qualitative components of this study, respectively.ResultsThe quantitative findings of this study showed that 64.27% of respondents (95% CI 59.53% to 68.74%) had a good awareness of regional disease outbreaks and of the COVID-19 pandemic. Only 9.59% of people had a positive opinion regarding local disease outbreaks, the COVID-19 pandemic, and the preventive and control measures that were employed in response to these (95% CI 7.11% to 12.83%). In addition, this study revealed that a small percentage of participants (i.e., 2.16%) used traditional control and preventive measures in response to the COVID-19 pandemic and local disease outbreaks.ConclusionLess than one-tenth of respondents had a favorable attitude toward local disease outbreaks, the current COVID-19 pandemic, and the preventive and control measures that were employed in response to these. In addition, only a small number of study participants had actually used conventional control and preventive measures in response to local disease outbreaks and the COVID-19 pandemic. Nearly two-thirds of respondents had a good understanding of the preventive and control measures that were employed in response to local disease outbreaks and the COVID-19 pandemic.

Objective To assess prevalence of intestinal parasite and associated factors among patients with human immune deficiency virus (HIV)/ acquired immune deficiency syndrome (AIDS) in Debre markos referral hospital, Amhara region, Ethiopia from 2015-2019RESULTS This study revealed that, out of 380 patients, the prevalence of intestinal parasites was found to be 24.2% with95%CI (18.9, 28.4). The most predominant parasite was both forms of Entamoeba histolytica 11.3% followed by G.lambilia 8.9%, Strongyloides sterocoralis 2.4%, but A.lumbricoid 0.8% and H.worm 0.8% were the least detected. ART status had significant association with prevalence of intestinal parasites (AOR =3.566, CI: 1.882, 6.758).