Perilaku hidup bersih dan sehat adalah salah satu gambaran kehidupan dari kebiasaan keluarga yang selalu mencermati dan menjaga kesehatan terhadap semua anggota keluarga. PHBS ditempatkan sebagai salah satu indikator pencapaian dalam meningkatkan derajat kesehatan terhadap program Sustainable Development Goals (SDGs) 2015-2030. Pencegahan penyakit yang dilakukan dapat dengan mengurangi atau menghilangkan faktor risiko dengan menerapkan PHBS. Puskesmas Galur II merupakan salah satu Puskesmas yang melakukan peninjauan terhadap Perilaku Hidup Bersih dan Sehat di desa Nomporejo. Pada tahun 2020 cakupan rumah tangga PHBS 16% yang sebelumnya pada tahun 2019 cakupan rumah tangga PHBS 48,67%. Tujuan penelitian ini adalah untuk mengetahui pengaruh pengetahuan, sikap, dan tindakan terhadap kesadaran dan Perilaku Hidup Bersih dan Sehat (PHBS). Teknik pengambilan sampel dengan metode non probability sampling dan penentuan sampel menggunakan purposive sampling. Sampel dalam penelitian ini berjumlah 120 sampel pada kelompok keluarga di Desa Nomporejo Kabupaten Kulon Progo Yogyakarta. Analisis pada penelitian ini dengan menggunakan SEM dengan software AMOS 24.0. Hasil penelitian menunjukkan bahwa pengetahuan berpengaruh signifikan terhadap kesadaran dalam kelompok keluarga. Sikap berpengaruh signifikan terhadap kesadaran dalam kelompok keluarga Tindakan tidak berpengaruh signifikan terhadap kesadaran dalam kelompok keluarga. Kesadaran berpengaruh signifikan terhadap PHBS pada kelompok keluarga. Kesimpulan dari penelitian ini adalah pengetahuan dan sikap berpengaruh signifikan terhadap kesadaran, tindakan tidak berpengaruh signifikan terhadap kesadaran, dan kesadaran berpengaruh signifikan terhadap PHBS.
Frequent and ongoing changes in organisations that are instigated by external factors can be a significant obstacle, but they can also spark transformations in the sustainability of the business model, unveiling fresh prospects in terms of technology or operations. The inevitable part of each company’s existence is the capability to adapt to the changes and use it to strengthen its competitiveness. Due to the increasing relevance of change management, it is necessary to analyse and accumulate the existing literature on this topic. The objective of the study is to identify the trends of impact and influence of scientific sources on the topic of change management. The research involved two tasks: to analyse the performance of activities in the scientific sources of change management and to create and analyse scientific networks in order to determine the impact and influence of publications. To understand the deeper approach of the publications in the scientific field of change management, the two main bibliometric analysis methods were performed: performance analysis and science mapping. It included the selection of the Scopus database, filtering scientific sources by the main keyword “change management” in the fields of business, management and accounting, and the use of bibliometric indicators. The results showed that the topic of change management started to become popular around 2000, and the most productive source is the Journal of Organisational Change Management. The general performance of the authors and publications was identified; furthermore, the impact and influence of the publications were determined. As can be seen from the research results, the change management topic is studied worldwide by scientists and business representatives.
A tirosinase é uma enzima que participa da biossíntese da melanina. Logo, é considerada uma enzima muito importante para alguns processos fisiológicos, além disso, está envolvida desde o processo de escurecimento de algumas frutas até a neurodegeneração do Parkinson. Assim, o ácido kójico é um importante metabólito que possui a propriedade de inibição da enzima tirosinase em relação a produção de melanina. Com isso, o ácido kójico é muito utilizado na medicina, caracterizando-se dessa forma como importante para certos tipos de tratamentos. Sendo assim, neste projeto utilizamos abordagens de modelagem molecular para análises de derivados do ácido kójico, alvo molecular contra a enzima tirosinase, inicialmente a otimização e parametrização foram realizadas através do método semi-empírico PM3. Posteriormente os métodos foram otimizados pelo método TFD, em seguida utilizando o programa computacional MVD foi realizado os cálculos de energia para as moléculas. Tendo como guia para a definição de parâmetros estruturais a estrutura do Tropolone para as análises computacionais visando o ácido kójico e seus derivados. Dessa forma, os resultados obtidos nas simulações chegaram à satisfação. Baseado nos valores de energia obtidos através das análises, os derivados 2,3,8 e 9 são sugeridos como moléculas potenciais candidatos a inibidores da tirosina.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.