Background. The objective of the research was to analyze the difference in the effectiveness patients' respiratory tracts in the post-inhalation general anesthesia in smoking and non-smoking patients in the Recovery Room. The effectiveness of respiratory tract in the post-anesthesia, especially inhalation general anesthesia, is highly influenced by the health system of lungs. Respiratory system disorder includes respiratory tract obstruction or some conditions which cause it, such as respiratory tract infection, emphysema and chronic bronchitis. One of the factors which is believed to be the cause of respiratory system disorder is smoking. Design of this study is cross sectional design. The research used descriptive analytic method. Results. The result of the research showed that 21 non-smoking respondents (56.8%) underwent secretion accumulation of < 10 cc, and 7 smoking respondents (18.9%) who smoked > 20 cigarettes a day underwent secretion accumulation of > 10 cc. It could be concluded that there was the difference in the secretion accumulation in the respondents of the post-inhalation general anesthesia in smoking and non-smoking patients of 10.2916. The result of independent t-test showed that there was significant difference in the effectiveness of respiratory tract in the post-inhalation general anesthesia in smoking and non-smoking patients at p-value=0.000 (α<0.05). It is recommended that the effectiveness of respiratory tract in the postinhalation general anesthesia in smoking and non-smoking patients be monitored in order to forestall the incidence of complication in the respiratory tract obstruction. Conclusion. It was conducted in the Recovery Room of RSUD dr. Pirngadi, Medan from January until October, 2016. The population was 217 patients in the post-inhalation general anesthesia, and 37 of them were used as the samples in which 16 respondents were smokers and 21 respondents were non-smokers, taken by accidental sampling technique, at the significance level of 95%.
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