Background: Obstructive Sleep Apnea Syndrome (OSAS) is a breathing disorder during sleep that can cause stopping breathing and trigger dangerous diseases. The main symptoms that can occur in OSAS patients are loud snoring and excessive daytime sleepiness so it can disrupt the quality of life and performance. Allergic rhinitis (AR) is one of the risk factors for OSAS, after age, obesity, sex, neck circumference, and anatomic abnormalities of the airway. Allergic rhinitis can disrupt the quality of sleep patients. Allergic rhinitis patient has a risk of OSAS due to obstruction of the upper airways so airflow to the lungs is obstructed.Objective: To analyze the relationship of allergic rhinitis with the incidence of Obstructive Sleep Apnea Syndrome (OSAS) in young adults.Methods: This study is an observational study with a cross-sectional design. Samples were obtained with a probability sampling method by consecutive sampling. The subject of this study were students of the Faculty of Medicine, Diponegoro University, aged 18-23 years. This study consisted of interviews, BMI examination, neck circumference examination, nose, and throat examination, fill the Epworth Sleepiness Scale (ESS) questionnaire to assess OSAS and the Score For Allergic Rhinitis (SFAR) questionnaire to assess allergic rhinitis. Statistical tests use chi-square, fisher's exact test, and logistic regression.Results: The incidence of allergic rhinitis with OSAS in young adults occurred as much as 79,7%. Bivariate analyze showed allergic rhinitis associated significantly with the incidence of OSAS in young adults (p=0,000; PR=12,3). The most common group of allergic rhinitis symptoms in allergic rhinitis patients with OSAS is the group of symptoms of sneezing, rhinorrhea, and nasal congestion.Conclusion: Allergic rhinitis patients risk 12,3 times more likely to suffer from OSAS than non-allergic rhinitis in young adults.Keyword: Allergic Rhinitis, OSAS, Young Adults
Latar belakang : Kehilangan pendengaran merupakan komplikasi otitis media kronik (OMSK) yang paling sering, jenis kehilangan pendengaran yang tersering adalah tuli konduktif, yang disebabkan oleh adanya air bone gap (ABG), ABG pada pasien OMSK mempunyai variasi yang berbeda-beda dan karakter yang khas berdasarkan faktor risiko. Tujuan : Menganalisis hubungan faktor risiko dengan ABG pada penderita OMSK. Metode : Penelitian desain observational analitik retrospektif di RSUP Dr Kariadi Semarang pada bulan September 2018 - Januari 2019. Data diambil dari rekam medis. jumlah sampel ditentukan sebanyak 100. Analisis data dengan uji chi-square. Hasil : Jenis kelamin laki-laki 46 orang, wanita 54 orang, rerata usia 32 tahun. Status osikula, lama sakit, kolesteatom, luas perforasi membran telinga berhubungan terhadap ABG (p <0,05). Kesimpulan : Faktor risiko (status osikula, lama sakit, kolesteatom, perforasi membran timpani) berhubungan dengan air bone gap pada penderita OMSK. Kata kunci : Air bone gap, faktor risiko, otitis media supuratif kronik. Background: Hearing loss is the most frequent complication of chronic otitis media (CSOM), hearing loss is usually caused by conductive deafness caused by the presence of an air bone gap (ABG). ABG in CSOM patients has different variations and distinctive characters based on the factors. Objective: To analyze the relationship of risk factors ABG in CSOM patients. Methods: Observational analytic study with a retrospective observational analytic design at Dr. Kariadi Hospital Semarang in September 2018 - January 2019. Subjects were 100 patients. Data retrieval is done based on medical records about history taking, physical examination and investigation. Data were analyzed by Chi-square test. Results: A total male 46 and female. Avarage age 32 years. Oscular status, duration of illness, cholesteatom, area of ??ear membrane perforation associated with ABG (p <0.05). Conclusion: Risk factors (osicular status, duration of illness, cholesteatom, tympanic membrane perforation) associated with air bone gap in CSOM patients. Keywords: Chronic supurative otitis media, air bone gap, risk factors
Background: Smoking is an unhealthy lifestyle causing health problems that may lead to high morbidity and mortality rates. One way to stop smoking habit is by replacing conventional cigarettes with electric cigarettes. Cigarette smoke exposure can trigger an inflammatory reaction that can be measured using Neutrophil Lymphocyte Ratio (NLR). Aim: Proving of NLR in electric smoker are higher than conventional smoker. Method: The research used descriptive analytic design. The number of samples were 34 people, divided into 17 people each group (conventional smoker and electric smoker). The subjects were asked to fill out a questionnaire and their blood samples were taken by 3 cc. Then, the blood samples were tested in a laboratory to obtain NLR values. The data was then analyzed using unpaired T-test. Result: NLR mean in the conventional smoker group is 1,364 ± 0,28 and 1,791 ± 0,49 in the electric smoker group. The unpaired T-test indicates there is significant difference in the value of NLR between conventional smoker and electric smoker (p=0,005). Conclusion: NLR in electric smoker are higher than conventional smoke.
Background: Allergy is a hypersensitivity reaction due to induction of specific IgE binding to allergens on the surface of mast cells. Interleukin-5 is an important marker of hypersensitivity inflammation reactions. Nigella sativa, contain active substance thymoquinone, can reduce inflammatory mediators. Zinc as anti-inflammatory by inhibit releasing mediators from mast cells. Objective was to determine the effect of Nigella sativa (NS) and zinc on IgE and IL-5 serum levels on ovalbumin-induced BALB/C mice.Methods: The study design was a true experiment with post-test only control group using BALB/C mice. The study was conducted at Sultan Agung Islamic University’s laboratory on March-June 2020. Inclusion criteria were female BALB C mice, 6-8 weeks, 22-25 grams, and healthy. Thirty mice were divided randomly into 5 groups; negative control, positive control, NS group, zinc group, and NS + zinc group. All groups treated for 28 days. Allergic reactions tested by skin test with OVA, intervention response assessed by IgE and IL-5 serum levels.Results: At the end of study completed, obtained 6 negative controls, 6 positive controls, 6 NS groups, 5 zinc groups, and 5 NS+zinc groups. Two mice s died before intervention completed. Serum IgE and IL5 levels were significantly difference between treatment groups (Kruskal Wallis test; p=0.007 and One-way ANOVA test; p=0.020). The result of logistic regression test, IgE levels was the most significant in the NS+zinc group (p=0.006) and IL-5 levels was the most significant in the zinc group (p=0.002)Conclusions: Nigella sativa, zinc, and its combination can reduce IgE and IL-5 serum levels of ovalbumin-induced BALB / C mice.
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