Granulocytic sarcoma (chloroma), a rare tumor usually associated with myelogenous leukemia, is capable of invading the meninges or brain parenchyma. Radiologic findings in a case of granulocytic sarcoma of the brain, as well as those in 11 previously reported cases of intracranial leukemic masses, are interpreted. On computed tomographic scans, the lesions can appear isodense or hyperdense, edema and necrosis are variable, and there is uniform enhancement following intravenous administration of contrast material. There may be some affinity for the posterior fossa.
SYNOPSIS IN INTERLINGUA ACTIVITATE OSTEOGENIC DE ODONTOBLASTOS IN TRANSPLANTATE PULPA DENTAL.-Intacte pulpa dental ab incisores de rattos adulte esseva transplantate subcutaneemente ad in animals homologe de un a quatro dies de etate con le objective de studiar le formation de tissu calcificate per le odontoblastos. Post le transplantation e le restauration de odontoblastos intacte, tanto spiculas de osso compacte como etiam osso spongiose de characteristicas simile a dentina esseva formate. Post 24 dies, le odontoblastos esseva circumferentiate de stratos de iste genere de osso. Odontoblastos que habeva previemente formate dentina comenciava producer osso quando illos esseva non plus in contacto con tissu oral. Formationes cellular simile a immatur structures dental esseva inducite per le odontoblastos in tissu fibrose de sito adjacente al transplantas.The ability of the osteoblast to form calcified tissue is not unique, and this capacity is shared with other mesenchymal cells under suitable conditions. The odontoblast is important in the formation of dentin, and its activity is similar to that of the osteoblast in intramembranous bone formation.1 After calcification of dentin, odontoblasts strongly resemble osteoblasts2 and, when grown in vitro, they are similar morphologically and cytochemically.3A 4Bone and dentin are closely related in both organic and inorganic composition,5 and information about odontoblasts can serve as another approach to the study of calcification.Dental transplants in a variety of sites have been observed to participate in the formation of hard tissues.5'-" These studies have been limited to tooth germs before calcification has begun. The tooth germ is a mixed organ of ectodermal and mesodermal derivatives with different nutritional requirements.noted. Adult odontoblasts that had been active in the formation of hard tissue were transplanted to animals to define further their role in the formation of calcified tissue and to make comparison with bone formation under other experimental conditions. Materials and MethodsThe incisors were removed from adult Sprague-Dawley strain rats, weighing 100 to 150 Gm., that had been killed by an overdose of ether. The surrounding bone was dissected away and the enamel organs, removed according to the technic of Reith,'2 were preserved for another study. The teeth were then split and the pulps removed. These were stored briefly in petri dishes containing phosphate-buffered saline solution with streptomycin and penicillin at 150 C.The pulps were transplanted to littermate Sprague-Dawley rats as follows: Group Ithree litters of 32 newborn rats; Group IItwo litters of 24 rats, 1 day old; Group IIIthree litters of 30 rats, 2 days old; Group IV-two litters of 28 rats, 3 days old, and Group V-two litters of 24 rats, 3 days old, thymectomized at birth.In each of the 138 rats, two transplants were made (a) in right and left groins, (b) in right and left neck regions, between the clavicle and mandible, or (c) in the groin and in the neck. The rats were anest...
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