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One hundred and seventy‐eight (178) Rh‐negative volunteers, distributed into a treated and control series of six groups each, were studied to establish: (i) approximately 70 per cent of Rh‐negative individuals are susceptible to being immunized by a single injection of Rh‐positive blood; (ii) that, for immunologically susceptible individuals, the frequency of immunization increases with the volume of Rh‐positive erythrocytes administered; and (iii) that a possible relationship exists between potency of Rh immune globulin and effectivity. This relationship can be used to calculate an effective dose of Rh immune globulin in the treatment of large feto‐maternal hemorrhages or accidental tranfusions of Rh‐positive blood to Rh‐negative women.