Background Lemierre syndrome is a potentially life-threatening disease, which affects otherwise healthy young adults and adolescents. It is characterized by acute neck vein thrombosis and septic embolism, usually complicating a bacterial infection. Data on the syndrome are sparse, particularly concerning arterial complications.
Methods We evaluated the frequency and patterns of cerebral arterial and cardiac involvement (“arterial complications”) in an individual patient level cohort of 712 patients, representing all cases described over the past 20 years in the medical literature who fulfilled the criteria: (1) bacterial infection in the neck/head site and (2) objectively confirmed thrombotic complication or septic embolism. The study outcomes were defined as all-cause in-hospital deaths and the occurrence of clinical sequelae at discharge or in the postdischarge period.
Results A total of 55 (7.7%) patients had an arterial complication. The most frequent arterial complications were carotid involvement (52.7%), stroke (38.2%), and pericardial complications (20%). Patients with an arterial involvement were more likely to be treated with a greater number of antibiotics (23 vs. 10%) and to receive anticoagulation. In addition, patients with arterial complications had a greater risk of all-cause death (n = 20/600, 3.3% vs. n = 6/52, 12%; odds ratio [OR]: 3.8; 95% confidence interval [CI]: 1.5–9.9) and late clinical sequelae (n = 49/580, 9.0% vs. n = 15/46, 35%; OR: 5.2; 95% CI: 2.65–10.37).
Conclusions While Lemierre syndrome is known to be primarily characterized by venous thromboembolic events, our results suggest that local or distant arterial complications may occur in approximately one-tenth of patients and may be associated with a greater risk of long-term sequelae and death.
Background and Aims
Large-bore catheter aspiration embolectomy reduces thrombus burden and right ventricle strain, and improves hemodynamics after pulmonary embolism (PE). Sparse data is available for patients with high-risk PE and contraindications to thrombolysis or thrombolysis failure, particulary if veno-arterial extracorporal membrane oxygenation (VA-ECMO) is required.
Methods
All patients with acute high-risk PE and contraindications to thrombolysis undergoing FlowTriever® percutaneuous embolectomy and VA-ECMO circulatory support (or standby) at the University Hospital Zurich between April 2021 and August 2022 were retrospectively analyzed. The primary outcome was the combination of recurrent PE, heart failure hospitalization, and all-cause death at 30 days.
Results
The analysis included 15 patients: mean age was 63.1 years and 14 (93%) were men. Overall, 4 (27%) patients presented with cardiac arrest, 8 (53%) with ongoing obstructive shock, and 3 (20%) with persistent arterial hypotension. VA-ECMO was implanted prior to aspiration embolectomy in 8 (53%) patients. Three of 7 patients without initial VA-ECMO support experienced periprocedural cardiac arrest, of whom 2 received ECMO support before completion of embolectomy. VA-ECMO weaning was successful in all patients after a mean of 5.4 days. There was one periprocedural death in a patient who did not receive VA-ECMO support following a periprocedural cardiac arrest. The primary outcome at 30 days occurred in 5 (33.3%; 95%CI 13.0-61.3%) patients.
Conclusions
This study provides preliminary evidence for the feasibility of percutaneous large-bore aspiration embolectomy in combination with VA-ECMO support (or standby) in patients with high-risk PE and contraindications to thrombolysis.
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