Re: Internal Jugular Vein and Cerebral Venous Sinus Infective Thrombophlebitis Detected With 99mTc-HMPAO White Blood Cell Scintigraphy

Valerio, Luca; Pleming, William

doi:10.1097/rlu.0000000000003536

Cited by 2 publications

(4 citation statements)

References 6 publications

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Section: Clinical Approach To Patients With Spementioning

confidence: 99%

“…20 Results from studies directly comparing the diagnostic accuracy of PET/CT scanning in SPE versus CXR or chest CT as well as its accuracy in SPE are needed before a specific role for PET/CT scanning in the evaluation of either suspected SPE or suspected CIED infection can be postulated. 36,37 Diagnosis should also provide characterization of the extent and nature of pulmonary involvement. SPE is frequently associated with lung empyema.…”

Section: Clinical Suspicion Diagnosis and Characterization Of Local I...mentioning

confidence: 99%

“…An alternative approach is the use of nuclear medicine techniques such as F-FDG PET/CT, which has been reported to have affected diagnosis and management in isolated cases of SPE, 35,39 although its added clinical value has not been studied systematically to date. 37 Treatment in all cases of SPE primarily involves antimicrobial therapy and, in many cases, surgical intervention at the primary nidus of infection or at distant sites of metastatic infection. Empiric antibiotic treatment should be initially broad and cover pathogens most often responsible for the primary infection.…”

Section: Identification Of the Source And Treatmentmentioning

confidence: 99%

Section: Clinical Approach To Patients With Spementioning

confidence: 99%

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Septic Pulmonary Embolism: A Contemporary Profile

Valerio

Baddour

2022

Semin Thromb Hemost

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Septic pulmonary embolism (SPE) is a rare clinical entity that is distinct from the classic and more common non-septic thrombotic pulmonary embolism. SPE should be suspected in patients with a systemic acute inflammatory reaction or sepsis who develop signs and symptoms of pulmonary involvement. The diagnosis of SPE depends on the specific radiologic finding of multiple, peripheral, nodular, possibly cavitated lesions. SPE should prompt an immediate search for the primary source of infection; typically, right-sided infective endocarditis, cardiac implantable electronic devices, and septic thrombophlebitis as a complication of bone, skin, and soft tissue infection including Lemierre's syndrome, indwelling catheters, or direct inoculation via injection drug use. Invasive treatment of the infection source may be necessary; in thrombophlebitis, the efficacy and safety of anticoagulation remain undefined. Blood cultures may be negative, particularly among patients with recent antibiotic exposure, and broad-spectrum antimicrobial therapy should be considered. The in-hospital mortality of SPE ranges up to 20% in published case series. While trends in the incidence of SPE are unknown, the opioid epidemic, the growing use of cardiac implantable electronic devices worldwide, and the reported increase in cases of septic thrombophlebitis may be leading to an escalation in SPE cases. We provide a contemporary profile of SPE and propose a clinical management algorithm in patients with suspected or confirmed SPE.

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Section: Clinical Approach To Patients With Spementioning

confidence: 99%