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The irreversible generation of entropy for two limiting cases of combined forced-convection heat and mass transfer in a two-dimensional channel are investigated. First, convective heat transfer in a channel with either constant heat flux or constant surface temperature boundary conditions are considered for laminar and turbulent flow. The entropy generation is minimized to yield expressions for optimum plate spacing and optimum Reynolds numbers for both boundary conditions and flow regimes. Second, isothermal convective mass transfer in a channel is considered, assuming the diffusing substance to be an ideal gas with Lewis number equal to unity. The flow is considered to be either laminar or turbulent with boundary conditions at the channel walls of either constant concentration or constant mass flux. The analogy between heat and mass transfer is used to determine the entropy generation and the relations for optimum plate spacing and Reynolds number. The applicable range of the results for both limiting cases are then investigated by non-dimensionalizing the entropy generation equation.