The introduction of paper chromatography and the availability of radio-iodide enabled Laidlaw (1949) to show that the circulating thyroid hormone was thyroxine and not thyroglobulin or a peptide, a conclusion supported by the work of Taurog, Chaikoff & Tong (1950) and Rosenberg (1951). After the discovery of tri-iodothyronine (Gross & Pitt- Rivers, 1952aRivers, , b, 1953a Roche, Lissitzky & Michel, 1952 a, b) it became clear that many of the earlier methods would not have been capable of differentiating between thyroxine and the new substance. The paper-chromatographic techniques * Part 1: Sprott & Maclagan (1955).
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