Maternal and fetal serum levels of total cortisol and cortisone, unbound cortisol, and corticosteroid-binding globulin in vaginal delivery and cesarean section

Talbert, Luther M.; Pearlman, William H.; Potter, H. Downing

doi:10.1016/0002-9378(77)90397-0

Cited by 36 publications

(11 citation statements)

References 22 publications

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“…In baboons, fetal cortisone concentrations increased between mid-and late pregnancy [14]. In the maternal plasma, the concentrations of cortisol exceeded those of cortisone in a manner similar to those in humans at term [15,50] and in baboons at midand late pregnancy [14].…”

Section: Discussionmentioning

confidence: 73%

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Placental Metabolism of Cortisol at Mid- and Late Gestation in Swine1

Klemcke

1995

Biology of Reproduction

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An experiment was conducted in pigs to determine the source of fetal cortisol at 50 (n = 5) or 100 days (n = 4) of gestation (term = 114 days). Equilibrium concentrations of tritiated cortisol were achieved, and all hormonal measures were made at 110, 130, 140, and 150 min in anesthetized pigs. Maternal plasma cortisol did not differ (p = 0.48) between 50 (70.2 +/- 7.4 ng/ml; mean +/- SEM) and 100 days (62.4 +/- 5.8 ng/ml). Conversely, fetal cortisol increased (p = 0.048) between 50 (8.5 +/- 2.5 ng/ml) and 100 days (24.2 +/- 4.2 ng/ml), and, at each gestational age, values were lower (p = 0.001) than those in maternal plasma. Plasma cortisone (15.1 +/- 2.3 ng/ml) did not change with gestational age (p = 0.42) in either compartment (maternal or fetal), nor did it differ between compartments (p = 0.08). Maternal cortisol accounted for 22.8 +/- 2.0% of fetal cortisol at 50 days of gestation, and this contribution decreased (p < 0.001) to 5.87 +/- 0.8% at 100 days. At both ages, maternal cortisol accounted for almost 50% of fetal cortisone. Metabolism of maternal cortisol by the entire uterofetoplacental unit was 8.4 +/- 1.7% at 50 days and 7.5 +/- 2.4% at 100 days (p = 0.76). The maternal metabolic clearance rate of cortisol increased 44% (p = 0.003) between 50 and 100 days (1.49 +/- 0.4 vs. 2.15 +/- 0.2 L/min). Hence at these gestational ages, the fetus--presumably the fetal adrenal--is the primary source of fetal plasma cortisol. The major contribution of maternal cortisol to fetal cortisone strongly suggests the presence of porcine placental 11 beta-hydroxysteroid dehydrogenase activity. Further, factors constituting the placental "barrier" that metabolize maternal cortisol to cortisone and other products may be major regulators of porcine fetal plasma cortisol and cortisone.

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Section: Discussionmentioning

confidence: 73%

“…Concentrations did not change with gestational age, nor did they differ between the two compartments. In humans [15,50] and baboons [14], cortisone concentrations in fetal blood exceed those in the mother near term. In baboons, fetal cortisone concentrations increased between mid-and late pregnancy [14].…”

Section: Discussionmentioning

confidence: 94%

Placental Metabolism of Cortisol at Mid- and Late Gestation in Swine1

Klemcke

1995

Biology of Reproduction

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“…1973). It has been suggested that cortisol levels rise rapidly in the human fetus with the spontaneous onset of labour (Talbert et al 1977;Murphy 1Y82) whilst other workers refute this (Martinsen et al 1982). Any dispute about a rise in fetal cortisol at parturition revolves around the role it might play in the induction of labour.…”

Section: Discussionmentioning

confidence: 99%

Cortisol concentrations in the umbilical artery and vein of breech‐presenting infants at term in relation to the method of delivery

Farquharson

Dyas

Pierrepoint

1985

BJOG

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Summary. Umbilical cord artery and vein cortisol levels and cord artery pH were measured in 32 breech deliveries. There was no detectable increase in fetal cortisol output in relation to fetal acidosis. It is considered t h a t elevation of fetal cortisol levels is caused by maternal transfer of this hormone transplacentally during stressful delivery rather than by enhanced fetal adrenal activity.

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“…Cortisol: 1 ( 20 ), 2 ( 21 ), 3 ( 22 ), 4 ( 23 ), 5 ( 24 ), 6 ( 25 ), 7 ( 26 ), 8 ( 27 ), 9 ( 28 ), 10 ( 29 ), 11 ( 30 ), 12 ( 31 ), 13 ( 32 ), 14 ( 33 ), 15 ( 34 ), 16 ( 35 ), 17 ( 36 ), 18 ( 37 ), 19 ( 38 ), 20 ( 39 ), 21 ( 40 ), 22 ( 41 ), 23 ( 42 ), 24 ( 43 ), 25 ( 44 ), 26 ( 45 ), 27 ( 46 ), 28 ( 47 ), 29 ( 48 ), 30 ( 49 ), 31 ( 50 ), 32 ( 51 ), 33 ( 52 ), 34 ( 53 ), 35 ( 54 ), 36 ( 55 ), 37 ( 56 ), 38 ( 57 ), 39 ( 58 ), 40 ( 59 ), 41 ( 60 ), 42 ( 61 ), 43 ( 62 ), 44 ( 63 ), 45 ( 64 ), 46 ( 65 ), and 47 ( 66 ); Norepinephrine: 1 ( 67 ), 2 ( 68 ), 3 ( 33 ), 4 ( 69 ), 5 ( 70 ), 6 ( 71 ), 7 ( 72 ), 8 ( 73 ), 9 ( 74 ), 10 ( 36 ), 11 ( 75 ), 12 ( 76 ), 13 ( 77 ), 14 ( 78 ), 15 ( 79 ), 16 ( 80 ), 17 ( 81 ), 18 ( 55 ), and 19 ( 66 ); and AVP: 1 ( 11 ), 2 ( 12 ), 3 ( 15 ...…”

Section: Surge In Fetal Stress Hormonesmentioning

confidence: 99%

Arginine Vasopressin and Copeptin in Perinatology

Evers

Wellmann

2016

Front. Pediatr.

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Arginine vasopressin (AVP) plays a major role in the homeostasis of fluid balance, vascular tonus, and the regulation of the endocrine stress response. The measurement of AVP levels is difficult due to its short half-life and laborious method of detection. Copeptin is a more stable peptide derived from the same precursor molecule, is released in an equimolar ratio to AVP, and has a very similar response to osmotic, hemodynamic, and stress-related stimuli. In fact, copeptin has been propagated as surrogate marker to indirectly determine circulating AVP concentrations in various conditions. Here, we present an overview of the current knowledge on AVP and copeptin in perinatology with a particular focus on the baby’s transition from placenta to lung breathing. We performed a systematic review of the literature on fetal stress hormone levels, including norepinephrine, cortisol, AVP, and copeptin, in regard to birth stress. Finally, diagnostic and therapeutic options for copeptin measurement and AVP functions are discussed.

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Maternal and fetal serum levels of total cortisol and cortisone, unbound cortisol, and corticosteroid-binding globulin in vaginal delivery and cesarean section

Cited by 36 publications

References 22 publications

Placental Metabolism of Cortisol at Mid- and Late Gestation in Swine1

Placental Metabolism of Cortisol at Mid- and Late Gestation in Swine1

Cortisol concentrations in the umbilical artery and vein of breech‐presenting infants at term in relation to the method of delivery

Arginine Vasopressin and Copeptin in Perinatology

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