Ninety-six Macaca mulatta were exposed to aerosol particles containing Pasteurella tularensis. Four different aerosols were employed that contained particle size distributions with median diameters of 2.1, 7.5, 12.5, or 24.0 Am. Size distributions were calculated only for those particles observed by phase microscope to contain organisms. Animals exposed to particles whose median diameters were either 2.1 or 7.5 ,4m were all infected and showed extensive infection of the lower respiratory tract, evidenced by large patches of consolidation with many necrotic foci on the surface. Death occurred in these animals 4 to 8 days after exposure. Monkeys exposed to 12.5or 24.0-,um median diameter particles presented involvement of the cervical and mandibular lymph nodes, evidenced by swelling and abscess formation. Thirty-eight of the 45 animals in this group were infected. Those animals succumbing to the disease died from 8 to 21 days after exposure. The respiratory LDM values increased from 14 to 4,447 cells as the median diameter was raised from 2.1 to 24.0 ,um.
lonene has been identified as a thermal degradation product of p-carotene.The 5-percent yield of ionene represents the largest amount of any compound thus far identified from the degradation. Experimental evidence has been obtained indicating the presence of ionene in a marine sediment subjected to the same temperature used to degrade f-carotene.
The conversion of certain bromo substituted triphenylethylenes via cyano-and ethyl imidate hydrochloride derivatives to the corresponding guanyl (amidino) substituted triphenylethylenes has been accomplished. Unsubstituted amidines, N-alkyl-, , -dialkyland N,N'-dialkylamidines were prepared and the amidine group was incorporated into various heterocyclic substituents. Structural modifications of the triphenylethylene moiety gave rise to amidine derivatives of triphenylethane, triphenylhaloethylene and 9-benzalfluorene. When cis-trans isomerism was possible, separation of isomers could be effected by fractional crystallization of the intermediate nitriles. A number of the amidines exhibited anti-inflammatory and antifungal activities.
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