The conversion of certain bromo substituted triphenylethylenes via cyano-and ethyl imidate hydrochloride derivatives to the corresponding guanyl (amidino) substituted triphenylethylenes has been accomplished. Unsubstituted amidines, N-alkyl-, , -dialkyland N,N'-dialkylamidines were prepared and the amidine group was incorporated into various heterocyclic substituents. Structural modifications of the triphenylethylene moiety gave rise to amidine derivatives of triphenylethane, triphenylhaloethylene and 9-benzalfluorene. When cis-trans isomerism was possible, separation of isomers could be effected by fractional crystallization of the intermediate nitriles. A number of the amidines exhibited anti-inflammatory and antifungal activities.
The particulate phases delivered from cigarettes containing 100 % Cytrel, 100 % flue-cured tobacco, and blends of Cytrel and tobacco have been extensively characterized. Approximately 70 % of Cambridge particulate matter (CPM) from 100 % Cytrel cigarettes has been defined. A considerably smaller fraction of CPM from 100 % tobacco cigarettes has been similarly defined because of its greater complexity. Only two of the components observed in the particulate phase, glyceroI and possibly sodium, were delivered in higher amounts by 100 % Cytrel cigarettes than by 100 % tobacco cigarettes. For all other species deliveries were lower from 100 % Cytrel cigarettes. In cigarettes containing blends of Cytrel and tobacco the deliveries of alI components were shown to follow an approximately linear relationship with blend level.
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