No abstract

Patients with chronic kidney disease (CKD) are prone to cardiovascular diseases secondary to abnormalities in both autonomic cardiac function and redox balance [myeloperoxidase (MPO) to paraoxonase 1 (PON1) ratio]. Although aerobic training improves both autonomic balance and redox balance in patients with CKD, the cardioprotective effects of resistance training (RT), with and without blood flow restriction (BFR), remain unknown. We aimed to compare the effects of RT and RT+BFR on antioxidant defence (PON1), pro-oxidative status (MPO), cardiac autonomic function (quantified by heart rate variability analysis) and renal function. Conservative CKD (stages 1 to 5 who do not need hemodialysis) patients (n = 105, 33 female) of both sexes were randomized into three groups: control (CTL; 57.6 ± 5.2 years; body mass index, 33.23 ± 1.62 kg/m 2), RT (58.09 ± 6.26 years; body mass index 33.63 ± 2.05 kg/m 2) and RT+BFR (58.06 ± 6.47 years; body mass index, 33.32 ± 1.87 kg/m 2). Patients completed 6 months of RT or RT+BFR on three non-consecutive days per week under the supervision of strength and conditioning professionals. Training loads were adjusted every 2 months. Heart rate variability was recorded with a Polar-RS800 and data were analysed for time and frequency domains using Kubios software. The redox balance markers were PON1 and MPO, which were analysed in plasma samples. Renal function was estimated as estimated glomerular filtration rate. The RT and RT+BFR decreased pro-oxidative MPO (RT, ∼34 ng/ml and RT+BFR, ∼27 ng/ml),

Patients in maintenance hemodialisys (HD) present sleep disorders, increased inflammation, unbalanced redox profiles, and elevated biomarkers representing endothelial dysfunction. Resistance training (RT) has shown to mitigate the loss of muscle mass, strength, improve inflammatory profiles, and endothelial function while decreasing oxidative stress for those in HD. However, the relation between those factors and sleep quality are inadequately described. The aim of this study was to verify the effects of 3 months of RT on sleep quality, redox balance, nitric oxide (NO) bioavailability, inflammation profile, and asymmetric dimethylarginine (ADMA) in patients undergoing HD. Our primary goal was to describe the role of RT on sleep quality. Our secondary goal was to evaluate the effect of RT on NO, metabolism markers, and inflammatory and redox profiles as potential mechanisms to explain RT—induced sleep quality changes. Fifty-five men undergoing maintenance hemodialysis were randomized into either a control (CTL, n = 25) and RT group (RTG; n = 30). Participants in the RT group demonstrated an improvement in sleep pattern, redox, inflammatory profiles, and biomarkers of endothelial function (NO 2 − and ADMA). This group also increased muscle strength (total workload in RT exercises of upper and lower limbs). These findings support that RT may improve the clinical status of HD patients by improving their sleep quality, oxidative and inflammatory parameters.

This study aimed to compare the effects of dynamic (DRT) and isometric (IRT) resistance training on blood glucose, muscle redox capacity, inflammatory state, and muscle strength and hypertrophy. Fifteen 12-week-old male Wistar rats were randomly allocated into three groups: control group (CTL), DRT, and IRT, n = 5 animals per group. The animals were submitted to a maximal weight carried (MWC; every 15 days) and maximum isometric resistance (MIR; pre- and post-training) tests. Both training protocols were performed five times a week during 12 weeks, consisting of one set of eight uninterrupted climbs for 1 min with a 30% overload of MWC. The animals in the IRT group remained under isometry for 1 min. The DRT group experienced greater MWC from pre- to post-training compared to the CTL and IRT groups (p < 0.0001). The DRT and IRT groups displayed similar gains in MIR (p = 0.3658). The DRT group exhibited improved glycemic homeostasis (p = 0.0111), redox (p < 0.0001), and inflammatory (p < 0.0001) balance as compared with CTL and IRT groups. In addition, the improved glycemic profile was associated with an increase in muscle strength and hypertrophy, improvement in redox balance and inflammation status. We conclude that DRT was more effective than IRT on increasing cross-sectional area, but not muscle strength, in parallel to improved blood glucose, inflammatory status, and redox balance.

High intensity functional training (HIFT) emphasizes constantly varied, high intensity, functional activity by programming strength and conditioning exercises, gymnastics, Olympic weightlifting, and specialty movements. Conversely, traditional circuit training (TCT) programs aim to improve muscular fitness by utilizing the progressive overload principle, similar movements weekly, and specified work-to-rest ratios. The purpose of this investigation was to determine if differences exist in health and performance measures in women participating in HIFT or TCT after a six-week training program. Recreationally active women were randomly assigned to a HIFT (n = 8, age 26.0 + 7.3 yrs) or TCT (n = 11, age 26.3 + 9.6 yrs) group. Participants trained three days a week for six weeks with certified trainers. Investigators examined body composition (BC), aerobic and anaerobic capacity, muscular strength, endurance, flexibility, power, and agility. Repeated-measures ANOVA were used for statistical analyses with an alpha level of 0.05. Both groups increased body mass (p = .011), and improved muscular endurance (p < .000), upper body strength (p = .007), lower body power (p = .029) and agility (p = .003). In addition, the HIFT group decreased body fat (BF) %, while the TCT group increased BF% (p = .011). No changes were observed in aerobic or anaerobic capacity, flexibility, upper body power, or lower body stair climbing power. Newer, high intensity functional exercise programs such as HIFT may have better results on BC and similar effects when compared with TCT programs on health and fitness variables such as musculoskeletal strength and performance.

Effects of combined resistance plus aerobic training on body composition, muscle strength, aerobic capacity, and renal function in kidney transplantation subjects. J Strength Cond Res 35(11): 3243-3250, 2021-Immunosuppression and a sedentary lifestyle may exacerbate complications such as early graft dysfunction and muscle loss, and reduce patient survival after kidney transplantation (KT). Therefore, the purpose of this study was to evaluate changes in body composition (BC), muscular strength, aerobic, and renal function in KT subjects submitted to combined resistance plus aerobic training. Twelve KT subjects were randomly assigned into groups: (G1) 12 weeks of combined training (3 males and 4 females, 54 6 3 years); or (G2) nonexercise control (5 females, 43 6 18 years). The subjects were evaluated for BC (dual-energy X-ray absorptiometry), estimated V Ȯ2 peak, right-hand maximal grip strength (RHMGS) and left-hand maximal grip strength (LHMGS), and renal function. Post-training revealed that G1 reduced body fat percentage (p 5 0.046), uric acid (D 5 20.87; p 5 0.023), urea (D 5 29.43; p 5 0.032), and creatinine (D 5 20.15; p 5 0.045), increased fat-free mass, estimated V Ȯ2 peak, RHMGS, LHMGS (p , 0.05), and estimated glomerular filtration rate (eGFR) (D 5 11.64; p 5 0.017). G2 increased urea (D 5 8.20; p 5 0.017), creatinine (D 5 0.37; p 5 0.028), and decreased eGFR (D 5 216.10; p 5 0.038). After 12 weeks, urea (D 5 24.94; p 5 0.013), uric acid (D 5 1.64; p 5 0.044), and creatinine (D 5 0.9; p 5 0.011) were lower, whereas eGFR (D 5 36.51; p 5 0.009) was higher in G1. These data indicate that combined training instigates positive changes in BC, muscular strength, aerobic capacity, and renal function after KT.

Muscle quality (the ratio of strength to lean muscle mass) might be a better indicator of muscle function than strength alone. Differences in muscle quality index (MQI) between octogenarians and young older adults remain unclear. The aims of the present cross-sectional study were to compare (1) MQI between octogenarians and young older adults, (2) lab versus field-based MQI tools, and (3) determine possible confounding factors affecting MQI in older adults. Compiled data from two cross-sectional studies included 175 younger and older adults (31 men and 144 women) with a mean age of 75.93± 9.49 years. Participants with age ≥ 80 years old were defined as octogenarians (n= 79) and < 80 years was defined as young older adults (n= 96). Laboratory MQI was derived from the ratio of grip strength to arm muscle mass (in kg) measured by dual-energy x-ray absorptiometry. Field-based MQI was quantified from the ratio of grip strength to body mass index (BMI). Octogenarians displayed lower field (P= 0.003) and laboratory MQI (P< 0.001) as compared with young older adults. There was a strong correlation effect between field MQI and laboratory MQI (P= 0.001, R= 0.85). BMI (P= 0.001), and diabetes mellitus (P= 0.001) negatively affected MQI. Women presented lower MQI (P= 0.001) values than men. In light of this information, rehabilitation specialists should consider the use of fieldbased MQI as a tool for evaluation and follow-up of older population.

Maintenance of glycemic and lipemic homeostasis can limit the progression of diabetic kidney disease. Resistance training (RT) is effective in controlling glycemia and lipemia in kidney disease; however, the effect of RT with blood flow restriction (RT+BFR) on these metabolic factors has not been investigated. We aimed to verify if chronic (6 months) RT and RT+BFR performed by patients with stage-2 chronic kidney disease (CKD) improves their glycemic homeostasis and immunometabolic profiles. Patients with CKD under conservative treatment (n = 105 (33 females)) from both sexes were randomized into control (n = 35 (11 females); age 57.6 ± 5.2 years), RT (n = 35 (12 females); age 58.0 ± 6.2 years), and RT+BFR (n = 35 (10 females); 58.0 ± 6.4 years) groups. Chronic RT or RT+BFR (6 months) was performed 3 times per week on non-consecutive days with training loading adjusted every 2 months, RT 50%–60%–70% of 1RM, and RT+BFR 30%–40%+50% of 1RM and fixed repetition number. Renal function was estimated with the glomerular filtration rate and serum albumin level. Metabolic, hormonal, and inflammatory assessments were analyzed from blood samples. Six months of RT and RT+BFR were similarly effective in improving glucose homeostasis and hormone mediators of glucose uptake (e.g., irisin, adiponectin, and sirtuin-1), decreasing pro-inflammatory and fibrotic proteins, and attenuating the progression of estimated glomerular filtration rate. Thus, RT+BFR can be considered an additional exercise modality to be included in the treatment of patients with stage 2 chronic kidney disease. Trial registration number: U1111-1237-8231. URL: http://www.ensaiosclinicos.gov.br/rg/RBR-3gpg5w/ , no. RBR-3gpg5w. Novelty: Glycemic regulation induced by resistance training prevents the progression of CKD. Chronic RT and RT+BFR promote similar changes in glycemic regulation. RT and RT+BFR can be considered as non-pharmacological tools for the treatment of CKD.