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Epithelial-mesenchymal transition (EMT) occurs in

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Background:Anthracycline is an antitumor agent of the topoisomerase inhibitor family. Results: Doxorubicin inhibits the expression of hypoxia-inducible genes, suppresses HIF-dependent migration of target tumors, and dampens angiogenic response of the host heart. Conclusion: Doxorubicin blocks recruitment of HIF heterodimers to the enhancer and inhibits hypoxia response. Significance: The pleiotropic effect of doxorubicin on HIF signaling provides a clue for understanding efficacy and toxicity of cancer chemotherapy.

The amide bond is one of the most pivotal functional groups in chemistry and biology. It is also the key component of proteins and widely present in synthetic materials. The majority of studies have focused on the formation of the amide group, but its postmodification has scarcely been investigated. Herein, we successfully develop the Michael additions of amide to acrylate, acrylamide, or propiolate in the presence of phosphazene base at room temperature. This amide Michael addition is much more efficient when the secondary amide instead of the primary amide is used under the same conditions. This reaction was applied to postfunctionalize poly(methyl acrylate-co-acrylamide), P(MA-co-Am), and it is shown that the amide groups of P(MA-co-Am) could be completely modified by N,N-dimethylacrylamide (DMA). Interestingly, the resulting copolymer exhibited tailorable fluorescence with emission wavelength ranging from 380 to 613 nm, which is a desired property for luminescent materials. Moreover, the emissions of the copolymer increased with increasing concentration in solution for all excitation wavelengths from 320 to 580 nm. Therefore, this work not only develops an efficient t-BuP 4 -catalyzed amide Michael addition but also offers a facile method for tunable multicolor photoluminescent polymers, which is expected to find a wide range of applications in many fields, such as in anticounterfeiting technology.

In this paper, we report radical polymerization in the presence of a peroxide monomer for the preparation of branched vinyl polymers.

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Here, we report the reversible complexation-mediated copolymerization (RCMcP) of vinyl and divinyl monomers for the synthesis of highly branched polymers.