Purpose: Non-Hodgkin's lymphoma (NHL) is a serious malignant disease. Delayed diagnosis will cause anemia, increased intracranial pressure, organ failure, and even lead to death. The current main trend in this area is to use deep learning (DL) for disease diagnosis. Extracting classification information from the digital pathology images by DL may realize the automated qualitative and quantitative analysis of NHL. Previously, DL has been used to classify NHL digital pathology images with some success. However, shortcomings still exist in the data preprocessing methods and feature extraction. Therefore, this paper presents a method for the classification of NHL subtypes based on the fusion of transfer learning (TL) and principal component analysis (PCA). Methods: First, the NHL digital pathology images were preprocessed by image division and segmentation and then input into the transfer models for fine-tuning and feature extraction. Second, PCA was used to map the extracted features. Finally, a neural network was used as a classifier to classify the mapped features. During the fine-tuning of the transfer models, two methods, freezing all feature extraction layers and fine-tuning all layers, were employed to select the optimal model with the best classification result among all the preselected transfer models. On this basis, the use of freezing the layers' location was discussed and analyzed. Results: The results show that the proposed method achieved average fivefold cross-validation accuracies of 100%, 99.73%, and 99.20% for chronic lymphocytic leukemia (CLL), follicular lymphoma (FL), and mantle cell lymphoma (MCL) tumor, and each category has standard deviations 0.00, 0.53, and 0.65, respectively, in the NHL reference dataset. The overall classification accuracy for fivefold cross-validation is 98.93%, which is an increase of 1.26% compared to the latest reported methods, having a lower standard deviation (1.00). Conclusion: The method proposed in this paper achieves a high classification accuracy and strong model generalization for the classification of NHL, which makes it possible to conduct intelligent classification of NHL in clinical practice. Our proposed method has definite clinical value and research significance.

Invasive ductal carcinoma(IDC) is the most common type of breast cancer which is the leading cause of cancer-related deaths in middle-aged women. Pathological analysis of biopsy is the gold standard for diagnosis of breast cancer, and early detection, diagnosis, and treatment can significantly increase the survival rate. This paper proposes a method for the automatic detection of IDC based on the fusion of multi-scale residual convolutional neural network (MSRCNN) and SVM. First, the patches from whole slide images(WSI) were preprocessed by data enhancement and normalization and then input into the MSRCNN for features extraction. Second, the extracted features were input to the SVM and are classified into two categories: healthy and diseased patches. Finally, it is restored to the WSI according to the coordinate information of the patches, therefore the IDC and healthy tissue regions were built. Experimental results show that after 5-fold cross-validation, our method obtained an average accuracy of 87.45±0.81%, an average balance accuracy of 85.7±0.95%, and an average F1 score of 79.89±1.11%. Consequently, it has important practical value and scientific research significance. INDEX TERMS Invasive ductal carcinoma, multi-scale residual convolution, automatic detection, SVM.

Breast cancer is one of the primary causes of cancer death in the world and has a great impact on women’s health. Generally, the majority of classification methods rely on the high-level feature. However, different levels of features may not be positively correlated for the final results of classification. Inspired by the recent widespread use of deep learning, this study proposes a novel method for classifying benign cancer and malignant breast cancer based on deep features. First, we design Sliding + Random and Sliding + Class Balance Random window slicing strategies for data preprocessing. The two strategies enhance the generalization of model and improve classification performance on minority classes. Second, feature extraction is based on the AlexNet model. We also discuss the influence of intermediate- and high-level features on classification results. Third, different levels of features are input into different machine-learning models for classification, and then, the best combination is chosen. The experimental results show that the data preprocessing of the Sliding + Class Balance Random window slicing strategy produces decent effectiveness on the BreaKHis dataset. The classification accuracy ranges from 83.57% to 88.69% at different magnifications. On this basis, combining intermediate- and high-level features with SVM has the best classification effect. The classification accuracy ranges from 85.30% to 88.76% at different magnifications. Compared with the latest results of F. A. Spanhol’s team who provide BreaKHis data, the presented method shows better classification performance on image-level accuracy. We believe that the proposed method has promising good practical value and research significance.

A data mining method finds hidden patterns in massive datasets for study. It is commonly used in high-tech fields such as image processing and artificial intelligence, due to its ability to compute data statistics and pattern processing problems efficiently. This study investigates data mining in multiobjective dynamic software development based on dynamic traffic congestion prediction. Since traffic data can fluctuate at any time, it is typically challenging to develop more accurate mathematical and theoretical models. We integrate data mining techniques into the software for predicting traffic congestion and develop a new algorithm for discriminating traffic congestion. Using a combination of the 3 criteria and the SVM algorithm, along with massive amounts of data, our prediction accuracy is significantly enhanced.