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Ac lass of artificial K + channels formed by pillararene-cyclodextrin hybrid molecules have been designed and synthesized.T hese channels efficiently inserted into lipid bilayers and displayed high selectivity for K + over Na + in fluorescence and electrophysiological experiments.The cation transport selectivity of the artificial channels is tunable by varying the length of the linkers between pillararene and cyclodexrin. The shortest channel showed specific transmembrane transport preference for K + over all alkali metal ions (selective sequence:K + > Cs + > Rb + > Na + > Li + ), and is rarely observed for artificial K + channels.T he high selectivity of this artificial channel for K + over Na + ensures specific transmembrane translocation of K + ,a nd generated stable membrane potential across lipid bilayers.

Five unimolecular channels with different lengths are presented. The varying length of these channels has significant impact on their transmembrane transport properties, which are directly correlated with their antimicrobial activity and inversely correlated with their haemolytic toxicity. By further structural optimization, these new channels could reach high antimicrobial activity and very low haemolytic toxicity, with the potential to serve as systemic antibiotics.

In recent years, 3D bioprinting has attracted broad research interest in biomedical engineering and clinical applications. However, there are two issues need to be solved urgently at present, the development of ink is the first pressing thing for 3D printing tissue engineering scaffold, other thing is the promotion of angiogenesis in the scaffold. Therefore, a gelatin/sodium alginate‐based hydrogel with protein‐rich is developed here, which is prepared by gelatin, sodium alginate, and soy protein/soy peptide powder. The prepared inks exhibit excellent shear‐thinning behavior, which contribute to extrusion‐based printing; also shown good crosslinking ability by calcium chloride. The macroporous composite scaffolds are printed by 3D printing using the developed ink and the physicochemical properties of the scaffolds are evaluated. Moreover, the cytocompatibility of printed scaffold is characterized by using human umbilical vein epidermal cells, results show that the scaffolds with soy protein and soy peptide powder can promote cell attach, spread, migration, and proliferation. The further research of chicken embryo allantoic membrane assay and animal experiment are carried, and results present that the scaffold can promote the growth of neo‐vessels in the scaffold, which means the developed ink with soy protein and soy peptide powder has great potential for angiogenesis.