In this work, a novel aluminum metal–organic framework
(Al-MOF)/N-2-hydroxyethylpiperazine-N′-ethane-sulfonic
acid (HEPES) system with an excellent electrochemiluminescence (ECL)
property was developed. First, Al-MOF was successfully synthesized
through a one-pot solvothermal method by using 9,10-di(p-carboxyphenyl)anthracene (DPA) as the organic luminescence ligand
and Al3+ as the metal node. Compared with DPA, Al-MOF showed
high ECL intensity and excellent stability without an additional coreactant
in the HEPES buffer. The corresponding ECL mechanism was studied in
detail, verifying HEPES was not only the buffer in the system but
also the coreactant of Al-MOF. In particular, the system of Al-MOF/HEPES
showed a high ECL efficiency of 30.0%, taking the Ru(bpy)3
2+ system as the standard. In addition, the ECL signal
of Al-MOF was effectively quenched by dopamine (DA). The biosensor
for HBV DNA detection was constructed through the ECL signal on–off–on
mode of DNA specific recognition integrated with the DNA walker signal
amplification strategy. The ultrasensitive detection for HBV DNA was
achieved with a linear range of 100 aM to 10 pM and a limit of detection
(LOD) of 62.1 aM. This work proposed a high-efficiency Al-MOF/HEPES
system, providing a new viewpoint for a coreactant-free system in
the field of ECL.
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