The direct depletion of lactate accumulated in the tumor microenvironment holds promise for cancer therapybut remains challenging.H erein, we report ao ne-pot synthesis of openwork@ dendritic mesoporous silica nanoparticles (ODMSNs) to address this problem. ODMSNs self-assembled through atime-resolved lamellar growth mechanism feature an openworked core and ad endritic shell, both constructed by silica nanosheets of % 3nm. With alarge pore size, high surface area and pore volume,O DMSNs exhibited ah igh loading capacity (> 0.7 gg À1)o fl actate oxidase (LOX) and enabled intratumoral lactate depletion by > 99.9 %, leading to antiangiogenesis,d own-regulation of vascular endothelial growth factor,and increased tumor hypoxia. The latter event facilitates the activation of ac o-delivered prodrug for enhancing antitumor and anti-metastasis efficacy.T his study provides an innovative nano-delivery system and demonstrates the first example of direct lactate-depletion-enabled chemotherapy.
Hollow spheres are charming objects in nature. In this work, an unexpected deflation–inflation asymmetric growth (DIAG) strategy is reported, generating hollow nanoparticles with tailored concave geometry for interface catalysis. Starting from aminophenol‐formaldehyde (APF) nanospheres where the interior crosslinking degree is low, fully deflated nanobowls are obtained after etching by acetone. Due to APF etching and repolymerization reactions occuring asymmetrically within a single particle, an autonomous inflation process is observed similar to a deflated basketball that inflates back to a “normal” ball, which is rare at the nanoscale. A nucleophilic addition reaction between acetone and APF is elucidated to explain the chemistry origin of the DIAG process. Interestingly, the deflated APF hollow spheres enable preferential immobilization of lipase in the concave domain, which facilitates the stabilization of Pickering emulsion droplets for enhanced enzymatic catalysis at the oil–water interface. The study provides new understandings in the designable synthesis of hollow nanoparticles and paves the way toward a wide range of applications of asymmetric architectures.
The direct depletion of lactate accumulated in the tumor microenvironment holds promise for cancer therapybut remains challenging.H erein, we report ao ne-pot synthesis of openwork@ dendritic mesoporous silica nanoparticles (ODMSNs) to address this problem. ODMSNs self-assembled through atime-resolved lamellar growth mechanism feature an openworked core and ad endritic shell, both constructed by silica nanosheets of % 3nm. With alarge pore size, high surface area and pore volume,O DMSNs exhibited ah igh loading capacity (> 0.7 gg À1)o fl actate oxidase (LOX) and enabled intratumoral lactate depletion by > 99.9 %, leading to antiangiogenesis,d own-regulation of vascular endothelial growth factor,and increased tumor hypoxia. The latter event facilitates the activation of ac o-delivered prodrug for enhancing antitumor and anti-metastasis efficacy.T his study provides an innovative nano-delivery system and demonstrates the first example of direct lactate-depletion-enabled chemotherapy.
Na-IVAl-DMSN acts as both antigen carriers and modulators to “hyperactivate” dendritic cells (DCs) via potassium (K+) efflux dependent pyroptosis, eventually leading to enhanced adaptive and innate immunity.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.