Mesoporous sodium four-coordinate aluminosilicate nanoparticles modulate dendritic cell pyroptosis and activate innate and adaptive immunity

Tang, Jie; Yang, Yang; Qu, Jingjing; Ban, Wenhuang; Song, Hao; Gu, Zhengying; Yang, Yannan; Cai, Larry; Theivendran, Shevanuja; Wang, Yue; Zhang, Min; Yu, Chengzhong

doi:10.1039/d1sc05319a

Cited by 13 publications

(11 citation statements)

References 73 publications

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“…Proinflammatory cytokines are able to mediate tumor cell death via multiple apoptotic pathways [ 34 – 36 ]. To determine the tumor-killing activity of Zn 2+ as an artificial proinflammatory cytokine, cell viability assay was carried out on 4T1, 3T3 and L02 cells.…”

Section: Resultsmentioning

confidence: 99%

Artificial Macrophage with Hierarchical Nanostructure for Biomimetic Reconstruction of Antitumor Immunity

Zhao,

Liu,

Wang

et al. 2023

Nano-Micro Lett.

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Artificial cells are constructed from synthetic materials to imitate the biological functions of natural cells. By virtue of nanoengineering techniques, artificial cells with designed biomimetic functions provide alternatives to natural cells, showing vast potential for biomedical applications. Especially in cancer treatment, the deficiency of immunoactive macrophages results in tumor progression and immune resistance. To overcome the limitation, a BaSO4@ZIF-8/transferrin (TRF) nanomacrophage (NMΦ) is herein constructed as an alternative to immunoactive macrophages. Alike to natural immunoactive macrophages, NMΦ is stably retained in tumors through the specific affinity of TRF to tumor cells. Zn2+ as an “artificial cytokine” is then released from the ZIF-8 layer of NMΦ under tumor microenvironment. Similar as proinflammatory cytokines, Zn2+ can trigger cell anoikis to expose tumor antigens, which are selectively captured by the BaSO4 cavities. Therefore, the hierarchical nanostructure of NMΦs allows them to mediate immunogenic death of tumor cells and subsequent antigen capture for T cell activation to fabricate long-term antitumor immunity. As a proof-of-concept, the NMΦ mimics the biological functions of macrophage, including tumor residence, cytokine release, antigen capture and immune activation, which is hopeful to provide a paradigm for the design and biomedical applications of artificial cells.

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Section: Resultsmentioning

confidence: 99%

Artificial Macrophage with Hierarchical Nanostructure for Biomimetic Reconstruction of Antitumor Immunity

Zhao,

Liu,

Wang

et al. 2023

Nano-Micro Lett.

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“…Studies on NMs and DCs have focused on their application in nanomedicine, particularly cancer therapy, including research on manipulating immune responses against tumors and novel vaccine formulations. Tang et al demonstrated that sodium-stabilized mesoporous alumino-silicate NMs induce pyroptosis in DCs by releasing a Na + surge in a pH-responsive manner ( Tang et al, 2022 ). This event subsequently triggers pro-inflammatory factor production, thereby amplifying antitumor immune responses.…”

Section: Definition and Classification Of Pyroptosismentioning

confidence: 99%

Nanomaterial-induced pyroptosis: a cell type-specific perspective

Wang,

Zeng

et al. 2024

Front. Cell Dev. Biol.

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This review presents the advancements in nanomaterial (NM)-induced pyroptosis in specific types of cells. We elucidate the relevance of pyroptosis and delineate its mechanisms and classifications. We also retrospectively analyze pyroptosis induced by various NMs in a broad spectrum of non-tumorous cellular environments to highlight the multifunctionality of NMs in modulating cell death pathways. We identify key knowledge gaps in current research and propose potential areas for future exploration. This review emphasizes the need to focus on less-studied areas, including the pathways and mechanisms of NM-triggered pyroptosis in non-tumor-specific cell types, the interplay between biological and environmental factors, and the interactions between NMs and cells. This review aims to encourage further investigations into the complex interplay between NMs and pyroptosis, thereby providing a basis for developing safer and more effective nanomedical therapeutic applications.

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“…[147] Tang et al reported that sodium-stabilized mesoporous aluminosilicate nanoparticles (Na-IV Al-DMSN) induced pyroptosis in DCs by releasing large amounts of Na + in a pH-responsive manner. [148] The resulting pyroptotic DCs released pro-inflammatory cytokines, such as IL-1𝛽 and IL-18, which activated peripheral DCs and NK cells, enhancing immune responses. [149,150] Furthermore, nanomaterials can also induce pyroptosis by disrupting normal mitochondrial metabolic processes.…”

Section: Pyroptosis Activation Via the Canonical Pathway-enhanced Imm...mentioning

confidence: 99%

Nanomaterials for Disease Treatment by Modulating the Pyroptosis Pathway

Wang

2023

Adv Healthcare Materials

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Pyroptosis differs significantly from apoptosis and cell necrosis as an alternative mode of programmed cell death. Its occurrence is mediated by the gasdermin protein, leading to characteristic outcomes including cell swelling, membrane perforation, and release of cell contents. Research underscores the role of pyroptosis in the etiology and progression of many diseases, making it a focus of research intervention as scientists explore ways to regulate pyroptosis pathways in disease management. Despite numerous reviews detailing the relationship between pyroptosis and disease mechanisms, few delve into recent advancements in nanomaterials as a mechanism for modulating the pyroptosis pathway to mitigate disease effects. Therefore, there is an urgent need to fill this gap and elucidate the path for the use of this promising technology in the field of disease treatment. This review article delves into recent developments in nanomaterials for disease management through pyroptosis modulation, details the mechanisms by which drugs interact with pyroptosis pathways, and highlights the promise that nanomaterial research holds in driving forward disease treatment.

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Mesoporous sodium four-coordinate aluminosilicate nanoparticles modulate dendritic cell pyroptosis and activate innate and adaptive immunity

Abstract: Na-IVAl-DMSN acts as both antigen carriers and modulators to “hyperactivate” dendritic cells (DCs) via potassium (K+) efflux dependent pyroptosis, eventually leading to enhanced adaptive and innate immunity.

Cited by 13 publications

References 73 publications

Artificial Macrophage with Hierarchical Nanostructure for Biomimetic Reconstruction of Antitumor Immunity

Artificial Macrophage with Hierarchical Nanostructure for Biomimetic Reconstruction of Antitumor Immunity

Nanomaterial-induced pyroptosis: a cell type-specific perspective

Nanomaterials for Disease Treatment by Modulating the Pyroptosis Pathway

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