To investigate the effect of complex amino acids of arginine-enriched and leucine-enriched on tumor growth in tumor-bearing rats during chemotherapy, the SD rats were each given a catheterization of jejunostomy and an inoculation of Walker-256 carcinosarcoma cells subcutaneously. Thirty-six rats were randomized into 3 groups: Group A (balance amino acidþNS), Group B (balance amino acid + 5-Fu), and Group C (complex amino acids of arginine-enriched and leucine-enriched + 5-Fu). Tumor weight, tumor inhibitory rate, the expression of PCNA and apoptosis, cell cycle were investigated. In addition, rat's survival time was observed. The G0/G1 phase ratio, apoptosis index and survival time increased from group A to C. Conversely, The S phase ratio, PCNA index and tumor weight decreased from group A to C, respectively. Our results suggest that complex amino acids of arginine-enriched and leucine-enriched could inhibit tumor growth and enhance the anti-tumor effect of 5-Fu chemotherapy.
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