Bacterial infection greatly affects the rate of wound
healing.
Both photothermal and photodynamic antibacterial therapies activated
by near-infrared (NIR) light with semiconductor nanomedicine are two
effective approaches to address bacterial infections, but they cannot
coexist synergistically to kill bacteria more efficiently because
of the limitation of the band structure. Here, inspired by the natural
core–shell structure and photosynthesis simultaneously, polypyrrole
(PPy) is synthesized in the two-dimensional restricted area of the
layered bismuth oxychloride (BiOCl) nanosheets through the in situ ultrasonic recombination method. The atomic-level
interface contact and bonding formed in the PPy-BiOCl intercalated
nanosheets not only improve the light-to-heat conversion capabilities
of PPy but also promote the transmission of PPy photogenerated charge
carriers to the BiOCl semiconductor. The nanocomposites take advantage
of the deeper tissue penetration under NIR light irradiation and exhibit
excellent photothermal and photodynamic synergistic antibacterial
activity. In addition, PPy-BiOCl intercalated nanosheets have good
biocompatibility and accelerate wound healing through their antimicrobial
activity and skin repair function. The space-confined synthesis of
thin PPy nanosheets in layered structures offers an efficient NIR
photoresponsive nanomedicine for the treatment of pathogen infection,
with promising applications in infected wound healing.
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