Summar)'Ileparin surface coating is one approach to improve the biocompatibility of existing blood pumps used for mechanical circulatorysupport. Experimental evaluation ofcentrifugal pumpswith heparin surface coating was performed during ope n chest left heart bypass (3 .7 IJ min ove r 6 hours) in two series of bovine ex periments. Eight calves (74 ± 4 kg) w ere perfused either by heparin surface coa ted equipme nt wit hout systemic hepa rinization or uncoat ed equipment wit h systemic heparinization (300 I. U.lkg bodywcig ht ; ACT > 400 5). A standa rd battery or analyses was performed befo re and at regular intervals after onset of perfusion .At the end of perfusion all pump-head s we re ge ntly rinsed . There we re no macroscopic clots for both groups whe reas macroscopic clots we re observed in uncoated tubings introduced for control in the group perfused withou t systemic heparinization . The hemodyn amics we re significantly better in the group perfused witho ut systemic hepa rinizatio n and mai ntained functional coagulation sys tem.Clinical application of he parin surface coa ted equipme nt during resection of thor aco-abd ominal aortic ane urysms is showing promising res ults in 12 patients.
Keyword sHeparin surface coating -Bloodpump -Left hea rt bypassMechani cal circulatory support
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