Temporary Lung Support Using an Intravascular Gas Exchanger

Lk, von Segesser; Bm, Weiss; Pašić, Miralem; Friedl, Herwig; Lachat, ML; Leskosek, B.; Spiess, Maiko Rafael; Turina, M

doi:10.1055/s-2007-1020128

Cited by 9 publications

(1 citation statement)

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“…19,20 Early clinical trials of the IVOX in critically ill patients revealed that approximately 25-30% of basal respiratory requirements were achievable, yielding distinct clinical benefit for select patients. [21][22][23][24][25][26] Further technical advances included modifications of fiber material to enhance gas exchange and the incorporation of pumps to promote active mixing. [27][28][29][30][31] In 1994, Conrad et al 32 summarized the findings of a large multinational database, in which 164 IVOX devices were evaluated in 160 patients who were symptomatic while receiving conventional ventilator support for respiratory failure.…”

Section: Discussionmentioning

confidence: 99%

Development of a Photolytic Artificial Lung: Preliminary Concept Validation

Dasse

Monzyk²,

Burckle³

et al. 2003

ASAIO Journal

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There is an established need for pulmonary technology capable of facilitated gas exchange in the blood, thereby bypassing the alveolar-capillary interface. To address this need, we emulated one of the best-known photolytic reactions in nature, photosynthesis, in which green plants use sunlight to drive the exchange of oxygen for carbon dioxide. Our goal in the current study was to demonstrate the feasibility of direct photolytic conversion of water to liquid phase oxygen (dissolved oxygen [DO]) in synthetic serum. To this end, we constructed a test flow cell consisting of a conductive coating of vacuum-deposited titanium (Ti) metal, adherent TiO2 (anatase), and MnO2, applied as a laminate to a glass substrate, and then immersed the device in Locke's-Ringer solution (synthetic blood serum). Long wavelength (low energy) ultraviolet A laser light, directed to the transparent glass slide, reproducibly resulted in the generation of an active form of oxygen (AO), which was subsequently converted directly by the catalytic action of MnO2 to DO. The absence of light activation provided an entirely null response. We conclude that the photolytic production of DO from water in a blood serum surrogate, with commensurate CO2 clearance, is feasible. A prototype photolytic module is proposed, which uses multiple parallel photolytic surfaces to improve system production capacity and CO2 clearance through selective gas-liquid separation from the oxygen-enriched fluid.

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