Effective image prior is necessary for image super resolution, due to its severely under-determined nature. Although the edge smoothness prior can be effective, it is generally difficult to have analytical forms to evaluate the edge smoothness, especially for soft edges that exhibit gradual intensity transitions. This paper finds the connection between the soft edge smoothness and a soft cut metric on an image grid by generalizing the Geocuts method [5], and proves that the soft edge smoothness measure approximates the average length of all level lines in an intensity image. This new finding not only leads to an analytical characterization of the soft edge smoothness prior, but also gives an intuitive geometric explanation. Regularizing the super resolution problem by this new form of prior can simultaneously minimize the length of all level lines, and thus resulting in visually appealing results. In addition, this paper presents a novel combination of this soft edge smoothness prior and the alpha matting technique for color image super resolution, by normalizing edge segments with their alpha channel description, to achieve a unified treatment of edges with different contrast and scale.

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Objectives/Hypothesis: To develop a deep-learning-based computer-aided diagnosis system for distinguishing laryngeal neoplasms (benign, precancerous lesions, and cancer) and improve the clinician-based accuracy of diagnostic assessments of laryngoscopy findings. Study Design: Retrospective study. Methods: A total of 24,667 laryngoscopy images (normal, vocal nodule, polyps, leukoplakia and malignancy) were collected to develop and test a convolutional neural network (CNN)-based classifier. A comparison between the proposed CNNbased classifier and the clinical visual assessments (CVAs) by 12 otolaryngologists was conducted. Results: In the independent testing dataset, an overall accuracy of 96.24% was achieved; for leukoplakia, benign, malignancy, normal, and vocal nodule, the sensitivity and specificity were 92.8% vs. 98.9%, 97% vs. 99.7%, 89% vs. 99.3%, 99.0% vs. 99.4%, and 97.2% vs. 99.1%, respectively. Furthermore, when compared with CVAs on the randomly selected test dataset, the CNN-based classifier outperformed physicians for most laryngeal conditions, with striking improvements in the ability to distinguish nodules (98% vs. 45%, P < .001), polyps (91% vs. 86%, P < .001), leukoplakia (91% vs. 65%, P < .001), and malignancy (90% vs. 54%, P < .001). Conclusions: The CNN-based classifier can provide a valuable reference for the diagnosis of laryngeal neoplasms during laryngoscopy, especially for distinguishing benign, precancerous, and cancer lesions.

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Convolutional sparse coding (CSC) can model local connections between image content and reduce the code redundancy when compared with patch-based sparse coding. However, CSC needs a complicated optimization procedure to infer the codes (i.e., feature maps). In this brief, we proposed a convolutional sparse auto-encoder (CSAE), which leverages the structure of the convolutional AE and incorporates the max-pooling to heuristically sparsify the feature maps for feature learning. Together with competition over feature channels, this simple sparsifying strategy makes the stochastic gradient descent algorithm work efficiently for the CSAE training; thus, no complicated optimization procedure is involved. We employed the features learned in the CSAE to initialize convolutional neural networks for classification and achieved competitive results on benchmark data sets. In addition, by building connections between the CSAE and CSC, we proposed a strategy to construct local descriptors from the CSAE for classification. Experiments on Caltech-101 and Caltech-256 clearly demonstrated the effectiveness of the proposed method and verified the CSAE as a CSC model has the ability to explore connections between neighboring image content for classification tasks.

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