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Boron-cross-linked graphene oxide/polyvinyl alcohol (B-GO/PVA) hydrogels with high-water-content and excellent mechanical properties are prepared by freeze/thaw and boron cross-linking methods.

Previous studies implicated the neuronal guidance molecule netrin-1 in attenuating myocardial ischemia-reperfusion injury. However, the tissue-specific sources and receptor signaling events remain elusive. Neutrophils are among the first cells responding to an ischemic insult and can be associated with tissue injury or rescue. We found netrin-1 levels were elevated in the blood of patients with myocardial infarction, as well as in mice exposed to myocardial ischemia-reperfusion. Selectively increased infarct sizes and troponin levels were found in Ntn1loxP/loxP Lyz2 Cre+ mice, but not in mice with conditional netrin-1 deletion in other tissue compartments. In vivo studies using neutrophil depletion identified neutrophils as the main source for elevated blood netrin-1 during myocardial injury. Finally, pharmacologic studies using treatment with recombinant netrin-1 revealed a functional role for purinergic signaling events through the myeloid adenosine A2b receptor in mediating netrin-1–elicited cardioprotection. These findings suggest an autocrine signaling loop with a functional role for neutrophil-derived netrin-1 in attenuating myocardial ischemia-reperfusion injury through myeloid adenosine A2b signaling.

Our results suggest that miR-23a may be involved in TNF-α-induced endothelial cell apoptosis through regulation of the caspase-7 and serine/threonine kinase 4-caspase-3 pathways.

Highly transparent ceramics of La‐doped 0.75Pb(Mg1/3Nb2/3)O3–0.25PbTiO3 were fabricated by a two‐stage sintering method from conventional raw materials. The ceramics exhibited a transparency as high as 65% for the infrared wavelength. Large quadratic electro‐optic coefficient of 66 × 10−16 (m/v)2 was obtained, which was the highest value reported so far in Pb(Mg1/3Nb2/3)O3–PbTiO3 ceramics. The ferroelectric phase inducing the threshold electric field Eth and the domain structure of the transparent ceramics were studied.

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Eu 2 O 3 -doped aluminoborosilicate glasses were prepared in air at high temperature. Luminescence measurements were used to investigate a valence change from Eu 31 to Eu 21 ions in the aluminoborosilicate glasses. The results showed that the doped Eu 31 ions were partially reduced to Eu 21 in the Eu 2 O 3 :RO-Al 2 O 3 -B 2 O 3 -SiO 2 (RO 5 CaO, SrO, BaO, Li 2 O) glasses, but not in the Eu 2 O 3 :RO-Al 2 O 3 -B 2 O 3 -SiO 2 (RO 5 Na 2 O, K 2 O) glasses. The changes of Eu reduction with different RO components were discussed with the variation of optical basicity of RO and with different valency of R cations. The effects of co-doping BaO and ZnO in aluminoborosilicate glasses on Eu reduction were also investigated and discussed.