Porous Nb-Ti-Ta alloy scaffolds for bone tissue engineering: Fabrication, mechanical properties and in vitro/vivo biocompatibility

Liu, Jue; Ruan, Jianming; Chang, Lin; Yang, Hailin; Ruan, Wei

doi:10.1016/j.msec.2017.04.088

Cited by 47 publications

(42 citation statements)

References 44 publications

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“…On the other hand, titanium alloys have superior strength, but contain ingredients that can be toxic or allergenic [41]. Metal alloys are applied as joint replacements and fracture-fixation implants, because of their good biocompatibility, corrosion resistance and strength [42,43]. Unfortunately, metals are not biodegradable, so there is usually a requirement to remove metallic implants, especially in the case of children [42].…”

Section: Methodsmentioning

confidence: 99%

Fabrication of Scaffolds for Bone-Tissue Regeneration

2019

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The present article describes the state of the art in the rapidly developing field of bone tissue engineering, where many disciplines, such as material science, mechanical engineering, clinical medicine and genetics, are interconnected. The main objective is to restore and improve the function of bone tissue by scaffolds, providing a suitable environment for tissue regeneration and repair. Strategies and materials used in oral regenerative therapies correspond to techniques generally used in bone tissue engineering. Researchers are focusing on developing and improving new materials to imitate the native biological neighborhood as authentically as possible. The most promising is a combination of cells and matrices (scaffolds) that can be fabricated from different kinds of materials. This review summarizes currently available materials and manufacturing technologies of scaffolds for bone-tissue regeneration.

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Section: Methodsmentioning

confidence: 99%

Fabrication of Scaffolds for Bone-Tissue Regeneration

2019

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“…In most cases, these alloys have used a modification of previously developed TZNT (Ti-Zr-Nb-Ta) and TMZF (Ti-Mo-Zr-Fe) systems, whose biocompatibility is well established. These developments have not been limited to solid components; multiple authors have reported the fabrication of implantable scaffolds from low modulus alloys [137][138][139][140]. The use of lattice or scaffold structures, enables further optimisation of mechanical response including reducing the effective stiffness of an implant, as discussed in Section 3.1.2.…”

Section: Low Modulus Alloysmentioning

confidence: 99%

Clinical, industrial, and research perspectives on powder bed fusion additively manufactured metal implants

Lowther

Louth

Davey

et al. 2019

Additive Manufacturing

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A B S T R A C TFor over ten years, metallic skeletal endoprostheses have been produced in select cases by additive manufacturing (AM) and increasing awareness is driving demand for wider access to the technology. This review brings together key stakeholder perspectives on the translation of AM research; clinical application, ongoing research in the field of powder bed fusion, and the current regulatory framework. The current clinical use of AM is assessed, both on a mass-manufactured scale and bespoke application for patient specific implants. To illuminate the benefits to clinicians, a case study on the provision of custom cranioplasty is provided based on prosthetist testimony. Current progress in research is discussed, with immediate gains to be made through increased design freedom described at both meso-and macro-scale, as well as long-term goals in alloy development including bioactive materials. In all cases, focus is given to specific clinical challenges such as stress shielding and osseointegration. Outstanding challenges in industrialisation of AM are openly raised, with possible solutions assessed. Finally, overarching context is given with a review of the regulatory framework involved in translating AM implants, with particular emphasis placed on customisation within an orthopaedic remit. A viable future for AM of metal implants is presented, and it is suggested that continuing collaboration between all stakeholders will enable acceleration of the translation process. fection or surgical complications [11][12][13].Currently, the majority of skeletal endoprostheses are produced from titanium (Ti) or cobalt chromium (CoCr) based alloys, which meet the criteria of durability, strength, corrosion resistance and a low immune response [14,15]. These characteristics however come at the cost of the high stiffness of these alloys in comparison to bone. Mismatch between the mechanical properties of bone and orthopaedic materials

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“…In a recent report on porous Nb–Ti–Ta alloys, it was demonstrated that the mechanical properties could be tailored for bone tissue engineering. The elastic modulus and strength as high as 2.08 GPa and 121.67 MPa, respectively, were reported . Bioactive glasses with hierarchical porosity are employed for filling and restoring osseous defects, as they are capable of bonding to the bone and induce new bone growth.…”

Section: Role Of Nanomechanics In Regenerative and Prosthetic Medicinementioning

confidence: 99%

The Role of Nanomechanics in Healthcare

Nautiyal

Alam

Balani

et al. 2017

Adv Healthcare Materials

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Nanomechanics has played a vital role in pushing our capability to detect, probe, and manipulate the biological species, such as proteins, cells, and tissues, paving way to a deeper knowledge and superior strategies for healthcare. Nanomechanical characterization techniques, such as atomic force microscopy, nanoindentation, nanotribology, optical tweezers, and other hybrid techniques have been utilized to understand the mechanics and kinetics of biospecies. Investigation of the mechanics of cells and tissues has provided critical information about mechanical characteristics of host body environments. This information has been utilized for developing biomimetic materials and structures for tissue engineering and artificial implants. This review summarizes nanomechanical characterization techniques and their potential applications in healthcare research. The principles and examples of label-free detection of cancers and myocardial infarction by nanomechanical cantilevers are discussed. The vital importance of nanomechanics in regenerative medicine is highlighted from the perspective of material selection and design for developing biocompatible scaffolds. This review interconnects the advancements made in fundamental materials science research and biomedical technology, and therefore provides scientific insight that is of common interest to the researchers working in different disciplines of healthcare science and technology.

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Porous Nb-Ti-Ta alloy scaffolds for bone tissue engineering: Fabrication, mechanical properties and in vitro/vivo biocompatibility

Cited by 47 publications

References 44 publications

Fabrication of Scaffolds for Bone-Tissue Regeneration

Fabrication of Scaffolds for Bone-Tissue Regeneration

Clinical, industrial, and research perspectives on powder bed fusion additively manufactured metal implants

The Role of Nanomechanics in Healthcare

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