A Cu-catalyzed oxidation of alcohols triggered by the radical difluoroalkylation of alkenes has been developed, providing facile access to a series of difluoroalkylated ketones or aldehydes in moderate to high yields. The concurrent realization of the catalytic oxidation of alcohols and difluoroalkylation of alkenes enables a highly efficient and attractive method for organic synthesis.

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Amino group modified phthalocyanines (Pcs) and their derivatives have attracted great attention in the field of photodynamic therapy (PDT) because of their satisfied anticancer activity. The existence of N atoms in these Pcs is very important because they not only provide water solubility of Pcs, but also greatly affect their PDT activity. To clear the influence of N atoms number on PDT activity of amino group modified Pcs and their derivatives, in this manuscript, two series of amine modified Pcs with different N atom number and their water soluble derivatives, hydrochloride and quaternizing derivatives were synthesized. Their photochemical and photobiology properties were studied and compared. The results indicated that with increasing the number on N atom, the reactive oxygen species (ROSs) generation ability, cancer cell uptaken ability and photoinduced anticancer activity were all increased in these ZnPcs.