Background Infant and young child feeding practice is a cornerstone of care for child development mentally and growth physically. Failure to proper infant and young child feeding practice is associated with increased risk of childhood morbidity and mortality. Objective To assess the prevalence of infant and young child feeding practice among 0-23 months of age children in irrigated and non-irrigated area of Dangila Woreda, North-west Ethiopia, 2021. Methods Community based comparative cross-sectional study was conducted from Dec 1, 2020 to Jun 1, 2021 with a total of 823 mothers who have infant and young children 0-23monthes of age in 9 selected Keebles were included in the study. Stratified sampling technic was implemented to select irrigated and non- irrigated kebeles and study units. Data was collected by face to face interview method. bivariate and multivariate analysis were used, variables with p<0.05, was taken as statistically significant and independently associated with infant and young child feeding practice. Adjusted odds ratio along with 95% confidence interval was used to assess the strength of the association. Result Among 823 households visited, 802 participants gave complete responses with response rate of 97.4%. The overall prevalence infant and young child feeding practice was 62.5%, of these 72.8%(95%CI: 67.5%, 76.1%)from irrigated and 52.2%(95%CI: 47.8%, 57.4%), from non-irrigated area had good practice of IYCF. Moreover, the study identified that ANC (AOR= 2.138, 95% CI: 1.085, 4.210), knowledge (AOR= 2.43, 95% CI: 0.275, 0.612), attitude (AOR= 1.687, 95% CI: 1.129, 2.520), PNC (AOR= 1.606, 95% CI: 1.154, 2.360) and women’s decision making (AOR= 1.941, 95% CI: 1.305, 2.888) were significant predictor for IYCF among 0-23months of age children. Conclusion The overall prevalence of infant and young child feeding practice was (62.5%) in the study area and had shown significant variation between irrigated and non-irrigated area. Infant and young child feeding practice is high as compared previous study. Women’s decision making, ANC follow up, PNC follow up, attitude and knowledge were identified as the intervention areas..