In recent years, carbon-based quantum dots as luminophores and co-reactants have aroused broad interest for their ability to function in electrochemiluminescence (ECL) sensors due to their unique features, including excellent biocompatibility, low toxicity, and water solubility. In this mini review, the synthesis methods of carbon-based quantum dots are firstly introduced.Then, the mechanism of carbon-based quantum dots as luminophores and co-reactants and their latest progress application in the detection of heavy metal ions are explored. Finally, the current challenges and potential future development directions of carbon-based quantum dots in ECL sensing filed for heavy metal ions analysis are summarized.
Accurate
determination of hazardous Hg2+ is particularly
essential for the environment safety and human health. In this work,
using Hg2+ as a bridge for the electrochemiluminescence
(ECL) reagent and the corresponding coreactant, a new type of self-enhanced
ECL nanomaterial was simply and controllably prepared for the first
time. In detail, tris (4,4′-dicarboxylicacid-2,2′-bipyridyl)
ruthenium(II) dichloride modified with DNA1 (Ru-DNA1) and graphite-like
carbon nitride quantum dots linked with DNA2 (QDs-DNA2) were used
as the ECL reagent and coreactant, respectively. In the presence of
Hg2+, they could be integrated together to form a self-enhanced
ECL nanomaterial (Ru-DNA1-Hg2+-QDs-DNA2) via the T-Hg2+-T duplex structure. The ECL signal strength was positively
proportional to the concentration of Hg2+. On this basis,
sensitive and selective detection of Hg2+ could be achieved
by simply modifying the ECL nanomaterial on the electrode surface.
Under the optimal experimental conditions, the proposed sensing strategy
expressed a superior linear relation with Hg2+ concentration
from 10 fM to 1 nM. Moreover, a low detection limit of 3.3 fM with
outstanding selectivity, repeatability, and stability for Hg2+ analysis was obtained. In addition, the proposed sensing strategy
exhibited reasonable accuracy for real sample assay compared with
the atomic fluorescence spectrometry method. From this work, it is
suggested that by programming the analytes and the corresponding recognition
element, other analytes might also be sensitively and selectively
detected using the proposed method.
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