A procedure has been developed to extract and recover minute amounts of delta-9-carboxytetrahydrocannabinol (THC-COOH) from urine. A new non-isotopic internal standard is introduced to permit a chromatographic assay of the metabolite. The method affords a 91% recovery of 20 ng/mL of the THC-COOH acid from spiked urine with the assurance of a 3.8% coefficient of variation.
A rapid and precise method for the isolation and identification of dihydrocodeine from urine is reported. The narcotic is isolated from urine using Sep-Pak® C18 cartridges for cleanup, requiring less than 30 min for preparation. Identification is performed by gas chromatography/mass spectrometry.
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