Mesenchymal stromal cells (MSCs) constitute a heterogeneous population of stromal cells with immunomodulatory and regenerative properties that support their therapeutic use. MSCs isolated from many tissue sources replicate vigorously in vitro and maintain their main biological properties allowing their widespread clinical application. To date, most MSC-based preclinical and clinical trials targeted immune-mediated and inflammatory diseases. Nevertheless, MSCs have antiviral properties and have been used in the treatment of various viral infections in the last years. Here, we revised in detail the biological properties of MSCs and their preclinical and clinical applications in viral diseases, including the disease caused by the severe acute respiratory syndromecoronavirus-2 (SARS-CoV-2) infection (COVID-19). Notably, rapidly increasing numbers of MSC-based therapies for COVID-19 have recently been reported. MSCs are theoretically capable of reducing inflammation and promote lung regeneration in severe COVID-19 patients. We critically discuss the rationale, advantages and disadvantages of MSC-based therapies for viral infections and also specifically for COVID-19 and point out some directions in this field. Finally, we argue that MSC-based therapy may be a promising therapeutic strategy for severe COVID-19 and other emergent respiratory tract viral infections, beyond the viral infection diseases in which MSCs have already been clinically applied.
Aware of the importance that insects have, as well as their influence, both in ecosystems and human activities, the group has always received prominence in several areas of knowledge. In order to enjoy this immense diversity, the first step is to recognize and classify them. For this, a light trap model was elaborated, using three different lights (black, cold white and warm white). The pitfall-style trap, which in addition to the lights contained a container with alcohol and detergent, was properly assembled. Insects were collected, analyzed and identified. These processes allowed analyzing the efficiency of the trap with different lamps in the capture of insects, as well as the Orders to which they belong. In the end, it was observed that the Order of highest index in the analysis was Homoptera, and that the trap whose light source was black light was the most efficient in quantitative capture, with a total of 497 insects, followed by warm cold white light, respectively.
Introduction: The undergraduate course in Biomedical Sciences has existed in Brazil since 1966. It has expanded strongly in the last two decades and is responsible for training professionals to diagnose and research the causes, effects, and pathological mechanisms of diseases that affect the population. Even after decades of implementation and considering the reasons that led to the creation of the course, the evaluation in which areas these professionals are working is still incipient. Objective: Our aim is to know if the Biomedical Sciences graduates are being absorbed by the market job and in which areas. Methods: The present work is a retrospective cross-sectional observational study, based on the data of the students who had graduated in the Federal University of the Triangulo Mineiro, Brazil, from the first class of the course in 2003, until the second half of 2018. Results: The study has shown that the course of Biomedical Sciences of a Federal institution in Brazil has low evasion and that most of the graduates migrated to post-graduation (62.3%). Moreover, the majority of the professionals are located in the Southwest region of the country and most of them work in one of the specific áreas linked to the course (70.3%). In addition, these professionals are more prone to ingress in the academic area. Conclusion: These findings demonstrate that, despite being disproportionately distributed in the country, there is still demand for these professionals and clearly indicate the importance of the Biomedical Sciences egresses to teaching and research in Brazil.
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