Background: Acne is chronic inflammatory disease with formation of papules, pustules, and nodules. Vitamin-D is fat soluble vitamin with immunomodulatory function, helps reducing inflammation. Objectives: assess frequency of serum vitamin-D deficiency among acne vulgaris patients and the effect of vitamin-D supplementation on acne grading. Method: the study was conducted on two phases, phase I was a cross-sectional study included measuring serum vitamin D level for 80 acne patients attending dermatology clinic at Menoufia University Hospital. Phase II was an interventional case control study where studied acne patients with vitamin-D deficiency (66 patients) were randomly divided into two groups; one group (33 patients) were treated with free Oral vitamin-D 2000IU/ tablet daily for two months in addition to regular acne treatment. The other group (33 patients) received traditional treatment for acne without vitamin-D supplementation and both groups were followed up clinically for two months. Results: frequency of vitamin-D deficiency among studied patients was 82.5%, there was statistically significant relation between vitamin-D deficiency and severity of acne as 27.3% and 9.1% of them had grade 3& 4 acne respectively versus 7.1% and zero% among acne patients with normal vitamin D. Vitamin-D deficiency is significantly prevalent among female patients (98.4%), there was significant improvement in acne grading after vitamin-D supplementation. Conclusion: There is a significant relation between vitamin-D deficiency and severity of acne vulgaris and vitamin -D has a good role in management of acne. So. It is recommended to evaluate the serum level of vitamin D in acne patients and provide vitamin D supplementation to vitamin D deficient patients beside topical treatments for acne.
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